| Autor: |
Wu, Yang-Lin, Zhang, Chen-Hui, Teng, Yun, Pan, Ying, Liu, Nai-Cheng, Liu, Pei-Xin, Zhu, Xu, Su, Xin-Lin, Lin, Jun |
| Rok vydání: |
2022 |
| DOI: |
10.6084/m9.figshare.20552296.v1 |
| Popis: |
Additional file 1: Fig. S1 Purity of bone marrow derived macrophages (BMDMs). Fig. S2 C3 and C4 inhibit NLPR3 inflammasome activated by CoCrMo alloy particles in macrophages. Fig. S3 C3 and C4 suppressed the pyroptosis induced by CoCrMo alloy particles. Fig. S4 C3 and C4 suppressed the pyroptosis in BMDMs. Fig. S5 C3 inhibits the NLRP3 inflammasome activation independently of GPCRs and HADC inhibitor, while C4 is dependent on GPR109A receptor. Fig. S6 Quantification of osteoclast-related proteins. Fig. S7 C3 and C4 inhibit osteoclast differentiation and formation in vivo. Fig. S8 Quantification of TRAP-positive multi-nucleated (≥ 5 nucleus) osteoclasts. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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