N-docosahexaenoyl, 3 hydroxytyramine : A dopaminergic compound that penetrates the blood-brain barrier and suppresses appetite
| Autor: | Victor E. Shashoua, Gary W. Hesse |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Docosahexaenoic Acids Dopamine media_common.quotation_subject Dopamine Agents Motor Activity Blood–brain barrier General Biochemistry Genetics and Molecular Biology Mice Internal medicine Appetite Depressants medicine Animals Tissue Distribution Carbon Radioisotopes General Pharmacology Toxicology and Pharmaceutics media_common chemistry.chemical_classification Drug Carriers Mice Inbred BALB C Degree of unsaturation Dose-Response Relationship Drug biology Membrane transport protein Dopaminergic Brain Fatty acid Appetite General Medicine Rats medicine.anatomical_structure Endocrinology chemistry Biochemistry Blood-Brain Barrier Docosahexaenoic acid biology.protein Subcellular Fractions medicine.drug |
| Zdroj: | Life Sciences. 58:1347-1357 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(96)00101-4 |
| Popis: | Fatty acids with varying chain lengths ( 2–22 carbon atoms long ) and degrees of unsaturation (0–6 double bonds) were used to synthesize dopaminergic compounds for a study of the carrier mediated transport of dopamine (DA) to the brain. The most active carrier was the all cis C22:6 fatty acid [docosahexaenoic acid,( DHA )]which increased DA uptake through the blood-brain barrier by greater than 7.5 fold. The DHA-DA compound, NMI 8739, depressed the general locomotor activity of mice in a dose dependent manner. It also suppressed the appetite of Balb c mice and Charles River rats by 50% and 95% respectively at a dose of 10 mg/kg. Daily administration of NMI-8739 for a three week period did not induce tolerance . These results demonstrate DHA's potential for the carrier mediated transport of small molecules to the brain. |
| Databáze: | OpenAIRE |
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