Hyperactivity in the Gunn rat model of neonatal jaundice: age-related attenuation and emergence of gait deficits
| Autor: | Kimberly G. Stanford, John A. Stanford, Delin Ma, Douglas C. Bittel, Steven M. Shapiro, Jeffrey M. Shuler, Stephen C. Fowler, Jean-Baptiste Le Pichon |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Gait Ataxia
Male medicine.medical_specialty Bilirubin Rats Gunn Hyperkinesis digestive system Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Gait (human) Physical medicine and rehabilitation 030225 pediatrics Age related Medicine Animals business.industry Age Factors Jaundice Gunn rat Surgery Jaundice Neonatal Rats chemistry Pediatrics Perinatology and Child Health medicine.symptom business human activities 030217 neurology & neurosurgery Locomotion |
| Zdroj: | Pediatric research |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | Background Neonatal jaundice resulting from elevated unconjugated bilirubin (UCB) occurs in 60–80% of newborn infants. Although mild jaundice is generally considered harmless, little is known about its long-term consequences. Recent studies have linked mild bilirubin-induced neurological dysfunction (BIND) with a range of neurological syndromes, including attention deficit-hyperactivity disorder. The goal of this study was to measure BIND across the lifespan in the Gunn rat model of BIND. Methods Using a sensitive force plate actometer, we measured locomotor activity and gait in jaundiced (jj) Gunn rats versus their non-jaundiced (Nj) littermates. Data were analyzed for young adult (3–4 months), early middle-aged (9–10 months), and late middle-aged (17–20 months) male rats. Results jj rats exhibited lower body weights at all ages and a hyperactivity that resolved at 17–20 months of age. Increased propulsive force and gait velocity accompanied hyperactivity during locomotor bouts at 9–10 months in jj rats. Stride length did not differ between the two groups at this age. Hyperactivity normalized and gait deficits, including decreased stride length, propulsive force, and gait velocity, emerged in the 17–20-month-old jj rats. Conclusions These results demonstrate that, in aging, hyperactivity decreases with the onset of gait deficits in the Gunn rat model of BIND. |
| Databáze: | OpenAIRE |
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