Serum Immune Profiling for Early Detection of Cervical Disease
| Autor: | Gitika Panicker, Karen S. Anderson, Elizabeth R. Unger, Paul Maranian, Radwa Ewaisha |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine HPV medicine.medical_specialty cervical cancer protein microarrays Protein Array Analysis Uterine Cervical Neoplasms serology Medicine (miscellaneous) Early detection Disease cervical intraepithelial neoplasia Cervical intraepithelial neoplasia Gastroenterology Antibodies Serology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Human papillomavirus 31 early detection NAPPA Pharmacology Toxicology and Pharmaceutics (miscellaneous) Cervix Early Detection of Cancer Cervical cancer Human papillomavirus 16 Human papillomavirus 18 biology business.industry virus diseases Cancer Uterine Cervical Dysplasia medicine.disease female genital diseases and pregnancy complications 3. Good health 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein Female Antibody business Research Paper |
| Zdroj: | Theranostics |
| ISSN: | 1838-7640 |
| Popis: | Background: The most recent (2012) worldwide estimates from International Agency for Research on Cancer indicate that approximately 528,000 new cases and 270,000 deaths per year are attributed to cervical cancer worldwide. The disease is preventable with HPV vaccination and with early detection and treatment of pre-invasive cervical intraepithelial neoplasia, CIN. Antibodies (Abs) to HPV proteins are under investigation as potential biomarkers for early detection. Methods: To detect circulating HPV-specific IgG Abs, we developed programmable protein arrays (NAPPA) that display the proteomes of two low-risk HPV types (HPV6 and 11) and ten oncogenic high-risk HPV types (HPV16, 18, 31, 33, 35, 39, 45, 51, 52 and 58). Arrays were probed with sera from women with CIN 0/I (n=78), CIN II/III (n=84), or invasive cervical cancer (ICC, n=83). Results: Abs to any early (E) HPV protein were detected less frequently in women with CIN 0/I (23.7%) than women with CIN II/III (39.0%) and ICC (46.1%, p |
| Databáze: | OpenAIRE |
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