Nephroprotective Effects of Synthetic Flavonoid Hidrosmin in Experimental Diabetic Nephropathy
| Autor: | Gonzalo Hernández, Inés Artaiz, Carmen Gomez-Guerrero, Jesús Egido, Tatiana Suárez-Cortés, Lucas Opazo-Ríos, Macarena Orejudo, Arturo Zazpe, Teresa Caro-Ordieres, Gema Marín-Royo, Luna Jimenez-Castilla |
|---|---|
| Přispěvatelé: | UAM. Departamento de Medicina |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Senescence
Physiology Medicina Clinical Biochemistry Diosmin Inflammation Diabetic nephropathy RM1-950 Pharmacology medicine.disease_cause Biochemistry Article albuminuria Diabetes mellitus Albuminuria Medicine oxidative stress Molecular Biology Hidrosmin business.industry hidrosmin diabetic nephropathy inflammation Cell Biology medicine.disease Streptozotocin Oxidative stress Therapeutics. Pharmacology medicine.symptom business Kidney disease medicine.drug |
| Zdroj: | Antioxidants; Volume 10; Issue 12; Pages: 1920 Antioxidants, Vol 10, Iss 1920, p 1920 (2021) Antioxidants Biblos-e Archivo. Repositorio Institucional de la UAM instname |
| ISSN: | 2076-3921 |
| DOI: | 10.3390/antiox10121920 |
| Popis: | Diabetes mellitus (DM) is a high‐impact disease commonly characterized by hyperglycemia, inflammation, and oxidative stress. Diabetic nephropathy (DN) is a common diabetic microvascular complication and the leading cause of chronic kidney disease worldwide. This study investigates the protective effects of the synthetic flavonoid hidrosmin (5‐O‐(beta-hydroxyethyl) diosmin) in experimental DN induced by streptozotocin injection in apolipoprotein E deficient mice. Oral administration of hidrosmin (300 mg/kg/day, n = 11) to diabetic mice for 7 weeks markedly reduced albuminuria (albumin‐to‐creatinine ratio: 47 ± 11% vs. control) and ameliorated renal pathological damage and expression of kidney injury markers. Kidneys of hidrosmin‐treated mice exhibited lower content of macrophages and T cells, reduced expression of cytokines and chemokines, and attenuated inflammatory signaling pathways. Hidrosmin treatment improved the redox balance by reducing prooxidant enzymes and enhancing antioxidant genes, and also decreased senescence markers in diabetic kidneys. In vitro, hidrosmin dose‐dependently reduced the expression of inflammatory and oxidative genes in tubuloepithelial cells exposed to either high‐glucose or cytokines, with no evidence of cytotoxicity at effective concentrations. In conclusion, the synthetic flavonoid hidrosmin exerts a beneficial effect against DN by reducing inflammation, oxidative stress, and senescence pathways. Hidrosmin could have a potential role as a coadjutant therapy for the chronic complications of DM. This work was supported by grants from the Spanish Ministry of Science and Innovation- FEDER funds (Retos Colaboración RTC2017-6089-1 and Retos Investigación RTI2018-098788-B-I00) and Instituto de Salud Carlos III (PI20/00487 and DTS 19/00093) |
| Databáze: | OpenAIRE |
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