Hungarian hereditary acatalasemia and hypocatalasemia are not associated with chronic hemolysis
| Autor: | M. Vitai, L. Góth |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Acatalasemia medicine.medical_specialty Adolescent Acatalasia Clinical Biochemistry Hemolysis Biochemistry Hemoglobins chemistry.chemical_compound Internal medicine medicine Humans Erythropoiesis Elméleti orvostudományok Hydrogen peroxide Aged chemistry.chemical_classification Hungary L-Lactate Dehydrogenase biology Chemistry Glutathione peroxidase Biochemistry (medical) General Medicine Orvostudományok Middle Aged Catalase medicine.disease Isoenzymes Endocrinology Immunology biology.protein Female Hemoglobin Metabolism Inborn Errors Peroxidase |
| Popis: | Two Hungarian acatalasemic and eight hypocatalasemic patients revealed normal erythropoesis. Contrary to their decreased defence system against the toxic hydrogen peroxide, the biochemical tests (serum catalase, serum hemoglobin, serum lactate dehydrogenase (LDH) ratio of LDH1 and LDH2 isoenzymes and serum haptoglobin) excluded hemolysis. The normal activity of glutathione peroxidase and the decreased catalase activity could prevent the lysis of the erythrocytes. In the presence of extremely high levels of hydrogen peroxide acute hemolysis may not be excluded; therefore, follow-up of these patients is required. |
| Databáze: | OpenAIRE |
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