Comparative in vitro diffusion studies for atenolol transdermal delivery system
| Autor: | Joanna S. Demou, Fotios M. Plakogiannis, Madiha B. Sidhom |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Active ingredient Mice Hairless Chromatography Chemistry Diffusion Absorption (skin) Pharmacology Administration Cutaneous Atenolol In vitro Dosage form Mice Drug Delivery Systems medicine Animals Molecular Medicine Liberation cardiovascular diseases General Pharmacology Toxicology and Pharmaceutics circulatory and respiratory physiology medicine.drug Transdermal |
| Zdroj: | Pharmaceutica Acta Helvetiae. 68:215-219 |
| ISSN: | 0031-6865 |
| DOI: | 10.1016/0031-6865(94)90050-7 |
| Popis: | The purpose of this study was to screen atenolol as a candidate for transdermal drug delivery, and to study the release of atenolol from various gels. The percent atenolol release over time profiles indicates that for all the gelling agents used the amount of atenolol released is decreased by increasing the polymer concentration in the gel. The amount of atenolol released was found to be higher from Klucel® gels, compared to Methocel® and Carbopol® gels, with Carbopol® gels giving the least release. In studying the effect of atenolol concentration in the gel, it was observed that the amount of atenolol released was increased by increasing the drug concentration in the donor up to a limit corresponding to an atenolol concentration of approximately 2%. This seems to resemble the saturation solubility of atenolol into the gels. Hairless mouse skin and TESTSKIN® LSE were used as in vitro skin models. |
| Databáze: | OpenAIRE |
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