Pulmonary Hamartoma Associated With Lung Cancer (PHALC Study): Results of a Multicenter Study
| Autor: | Francesco Puma, Erino A. Rendina, Antonio D'Andrilli, Mark Ragusa, Alfonso Fiorelli, Nicoletta Pia Ardò, G. Bocchialini, Marco Anile, Paolo Carbognani, Simona Sobrero, Francesco Sollitto, Nicola Serra, Mario Santini, Luigi Ventura, Beatrice Trabalza Marinucci, Federico Venuta, Domenico Loizzi, Annalisa Carlucci, Giacomo Argento, Roberta Rapana, Giovanni Vicidomini, Francesco Ardissone, Valentina Tassi |
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| Přispěvatelé: | Fiorelli, Alfonso, D'Andrilli, Antonio, Carlucci, Annalisa, Vicidomini, Giovanni, Argento, Giacomo, Trabalza Marinucci, Beatrice, Ardissone, Francesco, Rapanà, Roberta, Sobrero, Simona, Carbognani, Paolo, Ventura, Luigi, Bocchialini, Giovanni, Ragusa, Mark, Tassi, Valentina, Sollitto, Francesco, Loizzi, Domenico, Ardò, Nicoletta Pia, Anile, Marco, Puma, Francesco, Rendina, Erino Angelo, Venuta, Federico, Serra, Nicola, Santini, Mario |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Lung Neoplasms Hamartoma Enucleation Pulmonary Hamartoma Benign tumor 03 medical and health sciences hamartoma lung cancer pulmonary surgical resection aged humans lung retrospective studies smokers lung neoplasms 0302 clinical medicine medicine Humans 030212 general & internal medicine Lung cancer Lung Aged Retrospective Studies Smokers business.industry Pulmonary medicine.disease Surgery medicine.anatomical_structure 030228 respiratory system Multicenter study Surgical resection Population study business Wedge resection (lung) |
| Zdroj: | Lung |
| ISSN: | 1432-1750 0341-2040 |
| Popis: | Purpose Pulmonary hamartoma is the most common benign tumor of the lung. We analyzed a 20-year historical series of patients with pulmonary hamartoma undergoing surgical resection, aiming to evaluate the characteristics, the outcomes, and the association between hamartoma and lung cancer. Methods It was a retrospective multicenter study including the data of all consecutive patients with pulmonary hamartoma undergoing surgical resection. The end-points were to evaluate: (i) the characteristics of hamartoma, (ii) outcomes, and (iii) whether hamartoma was a predictive factor for lung cancer development Results Our study population included 540 patients. Upfront surgical or endoscopic resection was performed in 385 (71%) cases while in the remaining 155 (29%) cases, the lesions were resected 20 ± 3.5 months later due to increase in size. In most cases, lung sparing resection was carried out including enucleation (n = 259; 48%) and wedge resection (n = 230; 43%) while 5 (1%) patients underwent endoscopic resection. Only two patients (0, 2%) had major complications. One patient (0.23%) had recurrence after endoscopic resection, while no cases of malignant degeneration were seen (mean follow-up:103.3 ± 93 months). Seventy-six patients (14%) had associated lung cancer, synchronous in 9 (12%) and metachronous in 67 (88%). Only age > 70-year-old (p = 0.0059) and smokers > 20 cigarettes/day (p Conclusion PH was a benign tumor, with no evidence of recurrence and/or of malignant degeneration after resection. The association between hamartoma and lung cancer was a spurious phenomenon due to common risk factors. |
| Databáze: | OpenAIRE |
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