Association of eNOS gene polymorphisms with essential hypertension in the Han population in southwestern China
| Autor: | Li Sn, Tang Wr, Cun Y, Ouyang Hr, Yu Hj, Xiao Cj, Wang Y, Wu Yr, Li J |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty China Genotype Nitric Oxide Synthase Type III Single-nucleotide polymorphism Blood Pressure Biology Essential hypertension Polymorphism Single Nucleotide Sex Factors Asian People Gene Frequency Enos Risk Factors Internal medicine Genetics medicine SNP Humans Allele Molecular Biology Alleles Aged Base Sequence Haplotype General Medicine Odds ratio Sequence Analysis DNA Middle Aged biology.organism_classification medicine.disease Endocrinology Haplotypes Case-Control Studies Hypertension Female Polymorphism Restriction Fragment Length |
| Zdroj: | Genetics and molecular research : GMR. 10(3) |
| ISSN: | 1676-5680 |
| Popis: | Endothelial nitric oxide synthase (eNOS) plays an important role in maintaining blood pressure homeostasis and vascular integrity. Polymorphisms in the eNOS gene have been found to be associated with hypertension in different human populations, including Northern and Southern Chinese Han populations. To examine the relationship of three eNOS gene polymorphisms, T-786C (rs2070744), G894T (rs1799983), and G10T (rs7830), with hypertension in the Han population in southwestern China, we carried out a study of the genotypes of three SNPs in 510 hypertensive and 510 normotensive subjects from the Yunnan Province by using PCR-RFLP and sequencing. Our SNP analyses showed that the distribution of the T-786C polymorphism did not differ between patients and controls, and that G894T and G10T are significantly associated with hypertension in females, adjusted for covariates. Compared with the other haplotypes, haplotype H1 (TGG), carrying protective 10G and 894G alleles, significantly decreased the risk of increased essential hypertension in females, with an odds ratio of 0.68 (P = 10(-5)). These results suggest that the eNOS polymorphism is one of the factors contributing to the predisposition for essential hypertension in the Han population in southwestern China. |
| Databáze: | OpenAIRE |
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