Negative association between paraoxonase 2, anthropometric markers and metabolic syndrome
| Autor: | Constantin Ionescu-Tirgoviste, Andrada Mihai, Manuela Mitu, Daniela Lixandru, Simona Carniciu, Cristian Guja, Irina Stoian, Petruta R. Alexandru |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Antioxidant Waist medicine.medical_treatment Type 2 diabetes Biology Peripheral blood mononuclear cell General Biochemistry Genetics and Molecular Biology metabolic syndrome Internal medicine medicine Lactonase lcsh:QH301-705.5 General Immunology and Microbiology General Neuroscience medicine.disease Respiratory burst paraoxonase 2 Endocrinology lcsh:Biology (General) biology.protein type 2 diabetes Metabolic syndrome General Agricultural and Biological Sciences Body mass index total oxidant and antioxidant status |
| Zdroj: | Open Life Sciences, Vol 10, Iss 1 (2015) |
| ISSN: | 2391-5412 |
| Popis: | Background Metabolic syndrome (MS) has a great impact on cardiovascular mortality and morbidity. Our aim was to investigate the association of MS with some oxidant and antioxidant markers, including pro-and antioxidant status of peripheral blood mononuclear cells (PBMC) in newly diagnosed type 2 diabetic mellitus patients (ND-T2D). Methods 219 ND-T2D and 88 healthy subjects were divided in two groups according to the absence or presence of MS. Anthropometric measurements, routine blood tests, total oxidant status (TOS), total antioxidant status (TAS) and ELISA measurements were included. The PBMC capacity to release free radicals and to neutralize them was also determined by measuring the respiratory burst (RB) together with the lactonase activity of the intracellular antioxidant enzyme paraoxonase 2 (PON2). Results Comparing ND-T2D MS+ with those MS- the RB of the PBMC was significantly higher (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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