Early clinical outcomes of 3D-conformal radiotherapy using accelerated hyperfractionation without intracavitary brachytherapy for cervical cancer
Autor: | Koichi Wadasaki, Katsuhide Ito, Kanji Matsuura, Yuji Murakami, Masahiro Kenjo, Yuko Kaneyasu, Hirotoshi Tanimoto, Kazushi Fujita, Yasutoshi Hashimoto |
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Rok vydání: | 2007 |
Předmět: |
cervical cancer
medicine.medical_treatment Uterine Cervical Neoplasms Accelerated fractionation 3d conformal radiotherapy 3D-conformal radiotherapy Humans Medicine Stage (cooking) Aged Neoplasm Staging Aged 80 and over Cervical cancer business.industry external radiotherapy Intracavitary brachytherapy Dose fractionation Obstetrics and Gynecology medicine.disease Radiation therapy Treatment Outcome Oncology Total dose Female Dose Fractionation Radiation Radiotherapy Conformal business Nuclear medicine |
Zdroj: | Gynecologic Oncology. 104:11-14 |
ISSN: | 0090-8258 |
Popis: | Purpose/Objective To evaluate the outcome of cervical cancer patients unable to undergo conventional intracavitary brachytherapy (ICBT) treated with 3D-conformal radiotherapy (3DCRT) alone using accelerated hyperfractionation (AHF). Methods and materials We reviewed the records of 7 patients who had received definitive radiotherapy with 3DCRT alone using AHF for cervical cancer between 2002 and 2005. FIGO stage was IB (1), IIB (2), IIIA (1), IIIB (2), and IVA (1). The reason we did not perform ICBT was due to patient refusal. In 1 patient with stage IB, a total dose of 65.4 Gy was delivered by local irradiation (LI) only. In 1 patient with stage IIIA, a total dose of 60 Gy was delivered by LI only. In 5 patients with Stage IIB–IV, a median total dose of 70.8 Gy was delivered by combination of whole pelvic irradiation (median dose of 45 Gy) with LI. Median overall treatment time was 42 days. Results Median follow-up for survival patients was 17 months. Out of 7 patients, 6 patients had CR and 1 patient had PR. The response rate was 100%. The 2-year local control rate was 85.7%. Of these patients, 5 are alive without disease and 1 is alive with lung metastasis. Conclusions Our outcomes suggest that 3DCRT using AHF may be a promising as a definitive treatment for cervical cancer when ICBT is not able to be performed. |
Databáze: | OpenAIRE |
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