In vitro evaluation of electrochemically bioactivated Ti6Al4V 3D porous scaffolds
| Autor: | Maksym Pogorielov, Yevheniia Husak, Adam Mirek, Viktoriia Korniienko, Alexander D. Pogrebnjak, Oleksandr Oleshko, Amanzhol Turlybekuly, Alexandr Myakinin, Katarzyna Leśniak-Ziółkowska, Iryna Liubchak, Wojciech Simka, Rafal Banasiuk, Roman Andriiovych Moskalenko, Dmitry Dogadkin, Mikhael Bechelany |
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| Přispěvatelé: | Nazarbayev University [Kazakhstan], Sumy State University, Al-Farabi Kazakh National University, Institut Européen des membranes (IEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM), Nalecz Institute of Biocybernetics and Biomedical Engineering (IBIB), Silesian University of Technology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
3D printed Ti6Al4V scaffolds
Materials science Silver Antibacterial coating chemistry.chemical_element Metal Nanoparticles Bioengineering 02 engineering and technology 010402 general chemistry Gram-Positive Bacteria 01 natural sciences Silver nanoparticle Biomaterials Gram-Negative Bacteria medicine Alloys [CHIM]Chemical Sciences Porosity Titanium Tissue Scaffolds Ag nanoparticles Plasma electrolytic oxidation Titanium alloy Osteoblast 021001 nanoscience & nanotechnology In vitro 0104 chemical sciences Anti-Bacterial Agents medicine.anatomical_structure Chemical engineering chemistry Mechanics of Materials Cortical bone 0210 nano-technology |
| Zdroj: | Materials Science and Engineering: C Materials Science and Engineering: C, Elsevier, 2021, 121, pp.111870. ⟨10.1016/j.msec.2021.111870⟩ |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2021.111870⟩ |
| Popis: | International audience; Triply periodic minimal surfaces (TPMS) are known for their advanced mechanical properties and are wrinkle- free with a smooth local topology. These surfaces provide suitable conditions for cell attachment and prolifer-ation. In this study, the in vitro osteoinductive and antibacterial properties of scaffolds with different minimal pore diameters and architectures were investigated. For the first time, scaffolds with TPMS architecture were treated electrochemically by plasma electrolytic oxidation (PEO) with and without silver nanoparticles (AgNPs) to enhance the surface bioactivity. It was found that the scaffold architecture had a greater impact on the osteoblast cell activity than the pore size. Through control of the architecture type, the collagen production by osteoblast cells increased by 18.9% and by 43.0% in the case of additional surface PEO bioactivation. The manufactured scaffolds demonstrated an extremely low quasi-elastic modulus (comparable with trabecular and cortical bone), which was 5–10 times lower than that of bulk titanium (6.4–11.4 GPa vs 100–105 GPa). The AgNPs provided antibacterial properties against both gram-positive and gram-negative bacteria and had no significant impact on the osteoblast cell growth. Complex experimental results show the in vitro effectiveness of the PEO-modified TPMS architecture, which could positively impact the clinical applications of porous bioactive implants. |
| Databáze: | OpenAIRE |
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