Effects of Chronic Caffeine Administration on Behavioral and Molecular Adaptations to Sensory Contact Model Induced Stress in Adolescent Male Mice

Autor:	Mohamed M. Kamal, Jiang Tian, Michael Kamal Ibrahim, Roua Aref Nouh, Moustafa Sayed, Rajiv Tikamdas
Rok vydání:	2020
Předmět:	0301 basic medicine Male medicine.medical_specialty Hippocampus Adenosine A2A receptor Real-Time Polymerase Chain Reaction Social defeat 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Stress Physiological Internal medicine Caffeine Genetics medicine Animals Chronic stress Prefrontal cortex Maze Learning Social Behavior Genetics (clinical) Ecology Evolution Behavior and Systematics Swimming Social stress business.industry Frontal Lobe 030104 developmental biology Endocrinology chemistry Sodium-Potassium-Exchanging ATPase business Transcriptome 030217 neurology & neurosurgery Behavioural despair test
Zdroj:	Behavior genetics. 50(5)
ISSN:	1573-3297
Popis:	Previous studies have shown that caffeine attenuates stress-induced mood dysfunction and memory deterioration through neuronal adenosine A2A receptors antagonism. However, whether caffeine exerts this effect through modulating other molecular targets, which interfere with the resilience to social defeat stress in adolescent male mice is unknown. This study was conducted to investigate the role of caffeine in the behavioral responses to social stress induced by the sensory contact model (SCM) and the possible alteration of the gene expression level of Na/K ATPase pump. Adolescent male mice were exposed to SCM for 12 days. Caffeine was administered intraperitoneal daily for 14 days after SCM. The time spent in interaction zone, social interaction ratio, preference index to novel objects, time spent in the open arms and immobility time in forced swimming test were used to measure the locomotor activity, social avoidance, short-term memory, anxiety and depression in mice. The results showed that chronic treatment with caffeine for 14 days improved locomotor activity, reversed the avoidance of social behavior, improved preference to novel objects, and reversed depression induced by social defeat stress in adolescent male mice, suggesting the enhancement of the resilience to social defeat stress induced by caffeine. Moreover, caffeine treatment did alter gene expression levels of Na/K ATPase isoforms in both prefrontal cortex and hippocampus. Altered gene expression was significant in most cases and correlates with the observed behavioral changes. Taken together, our findings provide new insight into the effects of chronic caffeine administration on locomotor activity, social avoidance, short-term memory and depression in adolescent male mice exposed to SCM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e82a610dce356f953ce2c38d089909 https://pubmed.ncbi.nlm.nih.gov/32504257 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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