New insights into the biology and pathobiology of beta2-glycoprotein I
| Autor: | Steven A. Krilis, Peyman Mirarabshahi, Bill Giannakopoulos |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Beta2-Glycoprotein I
business.industry Autoantibody medicine.disease medicine.disease_cause Antiphospholipid Syndrome Autoimmunity Rheumatology immune system diseases Antiphospholipid syndrome beta 2-Glycoprotein I Immunology Beta 2-Glycoprotein I Medicine Humans skin and connective tissue diseases Clinical phenotype business Neuroscience Autoantibodies |
| Zdroj: | Current rheumatology reports. 13(1) |
| ISSN: | 1534-6307 |
| Popis: | β2-glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome. The central importance of understanding β2GPI physiology from the perspective of the rheumatologist is that it forms the foundation for understanding the pathophysiology underlying autoantibody generation, and the diverse mechanisms by which anti-β2GPI antibodies in complex with β2GPI may predispose an individual to the antiphospholipid syndrome clinical phenotype. This review examines some of the latest novel findings in this area. |
| Databáze: | OpenAIRE |
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