A model of wound healing in chronically radiation-damaged rat skin
| Autor: | Sydney M. Evans, Cameron J. Koch, Ann Schwentker, Marshall T. Partington, Stephen R. Thom, Bernett L. Johnson |
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| Rok vydání: | 1998 |
| Předmět: |
Dorsum
Cancer Research medicine.medical_specialty Neoplasms Radiation-Induced medicine.medical_treatment Skin flap Breaking strength Rats Sprague-Dawley Cicatrix Hyperbaric oxygen medicine Animals Skin Hyperbaric Oxygenation Wound Healing business.industry Dose-Response Relationship Radiation Rats Surgery Radiation therapy Radiation exposure Disease Models Animal Radiation Injuries Experimental Dose–response relationship Oncology Chronic Disease Female Wound healing business |
| Zdroj: | Cancer Letters. 128:71-78 |
| ISSN: | 0304-3835 |
| Popis: | The aim of this investigation was to develop a model for studying the chronic effects of radiation on wound healing in the rat. Six months after rats received a single radiation exposure of 20 Gy, a random-pattern dorsal skin flap was elevated. Two weeks after the flap was elevated, irradiated animals showed diminished scar formation and wound breaking strength, as compared with controls (P < 0.05). The effect of hyperbaric oxygen treatment was investigated in some rats who received 20 sessions at 2.4 atmospheres absolute for 90 min daily, 5 days per week, prior to flap elevation and 10 sessions after creation of the flap. Treated animals showed a trend toward improvements in wound breaking strength and scar formation (P = 0.06). A reproducible model of chronic radiation damage in the rat was established. Further studies involving investigations at times more that 2 weeks post-wounding are needed. |
| Databáze: | OpenAIRE |
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