Pharmacokinetic Interaction Study between the New Antiepileptic and CNS Drug RWJ-333369 and Carbamazepine in Healthy Adults
| Autor: | Dennis R. Doose, Tom Verhaeghe, Bhavna Solanki, Caiping Yao, Meir Bialer, Suchean Chien, Gerald Novak |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_treatment Cmax Pharmacology Drug Administration Schedule Pharmacokinetics medicine Humans Drug Interactions Neurotransmitter Agents Dose-Response Relationship Drug business.industry Half-life Drugs Investigational Carbamazepine Middle Aged Drug interaction Circadian Rhythm Anticonvulsant Neurology Area Under Curve Drug Design Concomitant Anticonvulsants Female Carbamates Neurology (clinical) Carisbamate business Half-Life medicine.drug |
| Zdroj: | Epilepsia. 47:1830-1840 |
| ISSN: | 1528-1167 0013-9580 |
| DOI: | 10.1111/j.1528-1167.2006.00815.x |
| Popis: | Summary: Purpose: To characterize the possible pharmacokinetic interaction between the new antiepileptic and CNS drug RWJ-333369 and carbamazepine (CBZ) following multiple dosing in healthy subjects. Methods: In an 8-week, open-label, sequential design study, 24 healthy adults received multiple-dose RWJ-333369 alone (5 days 250 mg q12h; 5 days 500 mg q12h), then after a 4-day washout, multiple-dose CBZ alone (3 days 100 mg q12h; 3 days 200 mg q12h; 22 days 300 mg q12h), and then combination of CBZ (300 mg q12h), and RWJ-333369 (5 days 250 mg q12h; 5 days 500 mg q12h). Results: At steady-state following multiple dosing, RWJ-333369 peak plasma concentration (Cmax) and area under the concentration-time-curve within the dosing interval (AUCss) increased in proportion to dose. The Cmax and AUCss of CBZ were similar when given alone or concomitantly with RWJ-333369. The 90% confidence intervals for the ratio of CBZ Cmax and AUCss with/without RWJ-333369 were: 94–104% and 95–104%, respectively (well within the equivalence range of 80–125%). When RWJ-333369 was administered with CBZ, its mean (SD) oral clearance increased from 3.2 L/h to 4.9 L/h and consequently its mean half-life was shortened from 10.4 (1.9) h to 7.4 (1.2) h, and mean AUCss and Cmax were reduced by 37% and 30%, respectively. Conclusions: There was no effect of multiple-dose RWJ-333369 on CBZ pharmacokinetics. CBZ induced RWJ-333369 clearance, resulting in shortened half-life and decreased exposure (AUCss) and Cmax. Concomitant administration of RWJ-333369 with CBZ was generally safe and tolerated. |
| Databáze: | OpenAIRE |
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