Extranodal extension in head and neck squamous cell cancer: is there a role for further stratification?
| Autor: | Nicoletta Gardenal, Margherita Tofanelli, Annalisa Gatto, Rossana Bussani, V. Shafiei, Erica Sacchet, Giancarlo Tirelli, Paolo Boscolo-Rizzo |
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| Přispěvatelé: | Tirelli, G., Tofanelli, M., Sacchet, E., Bussani, R., Shafiei, V., Gatto, A., Boscolo Rizzo, P., Gardenal, N. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
survival rate medicine.medical_specialty head and neck neoplasm medicine.medical_treatment extranodal extension head and neck neoplasms neoplasm staging Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Head and neck Survival rate Survival analysis Retrospective Studies Squamous cell cancer Squamous Cell Carcinoma of Head and Neck business.industry Extranodal Extension Significant difference Neck dissection Enema Prognosis digestive system diseases 030104 developmental biology Otorhinolaryngology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Neck Dissection Surgery Lymph Nodes Oral Surgery business |
| Popis: | To investigate the prognostic significance of the stratification of extranodal extension (ENE) into ENE minor (ENEmi, up to 2 mm) and ENE major (ENEma, over 2 mm) in non-HPV-related squamous cell cancers of the head and neck, we retrospectively reviewed microscopic slides from neck dissection specimens of ENE-positive patients and subcategorised them into ENEmi and ENEma. We then compared the two groups in terms of overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS). Forty-four patients with pathologically positive necks had ENE in the histological report. Twenty-six had ENEmi and 18 ENEma. The three-year OS was 46% in the ENEmi group and 38.9% in the ENEma group. DSS and DFS were 80.8% and 80.8%, respectively, in the ENEmi group and 61.1% and 77.8%, respectively, in the ENEma group. None of the comparisons revealed any statistically significant difference. The results of our survival analysis seem to show a trend towards better survival rates in the ENEmi group, particularly regarding OS. Nonetheless, extension of the tumour outside the lymph node capsule by more than 2 mm was not found to be significantly associated with any of the explored survival outcomes. |
| Databáze: | OpenAIRE |
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