L'interleukine-1 réduit la prise alimentaire et le poids corporel en agissant dans le noyau arqué de l'hypothalamus

Autor: Jan Pieter Konsman, Adrian D. Bristow, Léa Chaskiel, Rose Marie Bluthé, Anders Blomqvist, Robert Dantzer
Přispěvatelé: Neurobiologie intégrative (NI), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Bordeaux Segalen - Bordeaux 2, Laboratory of Integrative Immunophysiology, University of Illinois at Urbana-Champaign [Urbana], University of Illinois System-University of Illinois System-Integrative Immunology and Behavior Program, Unité de Psychoneuroimmunologie, Nutrition et Génétique (PsyNuGen), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Lipopolysaccharides
Male
0301 basic medicine
medicine.medical_treatment
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Interleukin-1beta
hypophagia
Rats
Sprague-Dawley
Eating
Behavioral Neuroscience
0302 clinical medicine
Neural Pathways
arcuate nucleus
Neuropeptide Y
neuropeptide Y Taxonomy Neuroanatomy
Receptor
Neurons
Chemistry
lipopolysaccharide
Interleukin
Neuropeptide Y receptor
Recombinant Proteins
3. Good health
Cytokine
Hypothalamus
Immunologi
Cytokines
medicine.medical_specialty
Immunology
Neuropeptide
Interleukin-1
Lipopolysaccharide
Hypophagia
Arcuate nucleus
Inflammation Manuscript category Neurosciences
03 medical and health sciences
Internal medicine
medicine
Animals
Endocrine and Autonomic Systems
Body Weight
Arcuate Nucleus of Hypothalamus
Saporins
Rats
Interleukin 1 Receptor Antagonist Protein
030104 developmental biology
Endocrinology
030217 neurology & neurosurgery
interleukin-1
Neuroscience
Zdroj: Brain, Behavior, and Immunity
Brain, Behavior, and Immunity, Elsevier, 2019, 81, pp.560-573. ⟨10.1016/j.bbi.2019.07.017⟩
ISSN: 0889-1591
1090-2139
DOI: 10.1016/j.bbi.2019.07.017⟩
Popis: International audience; Manuscript number BBI_2018_536_R2 Title Interleukin-1 reduces food intake and body weight in rat by acting in the arcuate hypothalamus Article type Full Length Article Abstract A reduction in food intake is commonly observed after bacterial infection, a phenomenon that can be reproduced by peripheral administration of Gram-negative bacterial lipopolysaccharide (LPS) or interleukin-1beta (IL-1β), a pro-inflammatory cytokine released by LPS-activated macrophages. The arcuate nucleus of the hypothalamus (ARH) plays a major role in food intake regulation and expresses IL-1 type 1 receptor (IL-1R1) mRNA. In the present work, we tested the hypothesis that IL-1R1 expressing cells in the ARH mediate IL-1β and/or LPS-induced hypophagia in the rat. To do so, we developed an IL-1β-saporin conjugate, which eliminated IL-R1-expressing neurons in the hippocampus, and micro-injected it into the ARH prior to systemic IL-1β and LPS administration. ARH IL-1β-saporin injection resulted in loss of neuropeptide Y-containing cells and attenuated hypophagia and weight loss after intraperitoneal IL-1β, but not LPS, administration. In conclusion, the present study shows that ARH NPY-containing neurons express functional IL-1R1s that mediate peripheral IL-1β-, but not LPS-, induced hypophagia. Our present and previous findings indicate that the reduction of food intake after IL-1β and LPS are mediated by different neural pathways.
Databáze: OpenAIRE
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