Identification of the predominant human NK cell effector subset mediating ADCC against HIV‐infected targets coated with BNAbs or plasma from PLWH
| Autor: | Ian Frank, Luis J. Montaner, Pablo Tebas, Emmanouil Papasavvas, Karam Mounzer, Roger Keith Reeves, Kyle Kroll, Costin Tomescu, Krystal Colon |
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| Rok vydání: | 2021 |
| Předmět: |
Antibody-dependent cell-mediated cytotoxicity
medicine.diagnostic_test Effector medicine.medical_treatment Immunology Antibody-Dependent Cell Cytotoxicity Degranulation Heterologous HIV Infections Immunotherapy HIV Antibodies CD16 Biology Lymphocyte Subsets Article Flow cytometry Killer Cells Natural Viral replication medicine Humans Immunology and Allergy Broadly Neutralizing Antibodies |
| Zdroj: | Eur J Immunol |
| ISSN: | 1521-4141 0014-2980 |
| Popis: | The potential of immunotherapy strategies utilizing BNAbs such as 3BNC117 and 10-1074 to limit viral replication while also facilitating clearance of HIV infected cells has heightened interest in identifying the predominant NK effector subset(s) capable of mediating Antibody Dependent Cellular Cytotoxicity (ADCC). Utilizing Advanced Poly-chromatic Flow Cytometry, we identified that CD57 positive NK cells from ART-suppressed PLWH expressed significantly higher levels of the CD16 FcγR Receptor, 2B4 ADCC co-receptor and HLA-DR activation marker while NKG2C positive NK cells expressed significantly higher levels of the CD2 ADCC co-receptor (p |
| Databáze: | OpenAIRE |
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