IFNγ−TNFα−IL2−MIP1α−CD107a+PRF1+ CD8 pp65-Specific T-Cell Response Is Independently Associated With Time to Death in Elderly Humans
| Autor: | Rafael Solana, Sara Ferrando-Martinez, Juan Delgado, Beatriz Dominguez-Molina, Joseph P. Casazza, M. Ángeles Muñoz-Fernández, Manuel Leal, Rafael de la Rosa, Rebeca S. de Pablo-Bernal, Richard A. Koup, Ezequiel Ruiz-Mateos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Senescence
Male Aging Chemokine medicine.medical_treatment CD8-Positive T-Lymphocytes Viral Matrix Proteins Interferon-gamma Immune system Antigen Lysosomal-Associated Membrane Protein 1 Risk Factors Cause of Death Medicine Humans Perforin production Aged Aged 80 and over biology business.industry Perforin Tumor Necrosis Factor-alpha Tumor Suppressor Proteins virus diseases Middle Aged Flow Cytometry Phosphoproteins Survival Analysis Vaccination Cytoskeletal Proteins Cytokine C-Reactive Protein Phenotype Immunology Cytomegalovirus Infections biology.protein Interleukin-2 Original Article Female Geriatrics and Gerontology business Carrier Proteins CD8 |
| Popis: | Persistent cytomegalovirus (CMV) infection has been suggested to be a major driving force in the immune deterioration and an underlying source of age-related diseases in the elderly. CMV antibody titers are associated with lower responses to vaccination, cardiovascular diseases, frailty, and mortality. CMV infection is also associated with shorter T-cell telomeres and replicative senescence. Although an age-related deregulation of CMV-specific T-cell responses could be an underlying cause of the relationship between CMV and immune defects, strong and polyfunctional responses are observed in elderly individuals, casting uncertainty on their direct role in age-related immune frailty. In this study, we longitudinally followed a cohort of healthy donors aged over 50 years, assessing their mortality rates and time to death during a 2-year period. Specific T-cell responses to the immunodominant antigen pp65 (IFNγ, TNFα, IL2, MIP1α, CD107a, and perforin production) were analyzed at the beginning of the 2-year observation period. A cytotoxic CD8 pp65-specific T-cell response, without cytokine or chemokine coexpression, was independently associated with all-cause mortality in these elderly individuals. This pp65-specific CD8 T-cell response could be a useful tool to identify individuals with depressed immune function and a higher risk of death. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|