In vivo efficacy of chloroquine treatment for Plasmodium falciparum in Malawian children under five years of age
| Autor: | Carlos C. Campbell, David L Heymann, Jack J. Wirima, Charles O. Khoromana |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Malawi Plasmodium falciparum Administration Oral Parasitemia Chloroquine Virology Internal medicine parasitic diseases Epidemiology medicine Humans biology Under-five business.industry medicine.disease biology.organism_classification Malaria Regimen Infectious Diseases El Niño Child Preschool Immunology Drug Evaluation Parasitology business medicine.drug |
| Zdroj: | The American journal of tropical medicine and hygiene. 35(3) |
| ISSN: | 0002-9637 |
| Popis: | In 1984 the government of Malawi instituted a program to reduce malaria mortality and morbidity in children less than 5 years of age as a part of the Combatting Childhood Communicable Diseases (CCCD) program. To define the appropriate malaria therapy regimen, investigators used a quality assurance design in a simplified 7-day in vivo drug response study with follow-up observations on day 2 (D2), D3, and D7 after the initial day of the study (D0). The efficacy of oral chloroquine was assessed in 224 children who were enrolled at 6 sites, 2 in each of the 3 administrative regions of Malawi. Parasitological failure, defined as failure of parasitemia to decrease by 75% of the value by D3 or presence of any detectable parasitemia on D7, ranged from 41%-65% following administration of chloroquine 25 mg (base)/kg. However, only 8% of children who were parasitemic on D7 were febrile or judged to be ill. Considering these therapeutic results and the higher cost and limited availability of alternative therapies, chloroquine 25 mg/kg therapy was adopted as the primary therapy for malaria. |
| Databáze: | OpenAIRE |
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