Serum adiponectin and resistin: Correlation with metabolic syndrome and its associated criteria among temiar subtribe in Malaysia
| Autor: | Mohd Nizam Zahary, Mohd Adzim Khalili Rohin, Nur Haslinda Ridzwan, Mimie Noratiqah Jumli, Azizul Fadzli Wan Jusoh, Nur Sakinah Harun, Rosliza Yahaya, Nik Ahmad Shaiffudin Nik Him |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 030204 cardiovascular system & hematology High cholesterol Body Mass Index 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Internal Medicine Medicine Humans Resistin National Cholesterol Education Program Aged Metabolic Syndrome Adiponectin business.industry Metabolic disorder Malaysia nutritional and metabolic diseases General Medicine Middle Aged medicine.disease Prognosis Obesity Lipids Endocrinology Cross-Sectional Studies Case-Control Studies Female Metabolic syndrome Waist Circumference business hormones hormone substitutes and hormone antagonists Biomarkers Follow-Up Studies |
| Zdroj: | Diabetesmetabolic syndrome. 13(3) |
| ISSN: | 1878-0334 |
| Popis: | Metabolic syndrome (MetS) is characterized as a cluster of metabolic disorder including increased blood pressure, elevated blood glucose level, high cholesterol level and visceral fat obesity. Polypeptide hormones such as adiponectin and resistin play a significant role in glucose and lipids metabolism, liver and pancreas function. This study aimed to investigate the relationship between serum adiponectin and resistin with MetS criteria among Temiar subtribe in Kuala Betis.This cross sectional study involved 123 subjects from Temiar subtribe in Kuala Betis, Gua Musang, Kelantan. MetS criteria were measured according to standard protocol by modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guideline. Anthropometric and biochemical measurements were performed including serum adiponectin and resistin for every study subjects.Serum adiponectin was significantly lower in MetS subjects (7.98 ± 5.65 ng/ml) but serum resistin was found to be significantly higher in MetS subjects (11.22 ± 6.34 ng/ml) compared to non-MetS subjects with p 0.001 and p = 0.002 respectively. Serum adiponectin was negatively correlated with most of the cardio-metabolic risk factors; BMI, waist circumference, systolic and diastolic blood pressure, fasting blood glucose, triglyceride and total cholesterol. Serum resistin was found to be positively correlated with BMI, waist circumference, fasting blood glucose and total cholesterol.The difference in serum adiponectin and resistin level among MetS individuals indicated the potential of serum adiponectin and resistin to be used as a biomarker for the diagnosis of MetS among Temiar subtribe. |
| Databáze: | OpenAIRE |
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