Synthesis and characterization of silver(I) complexes bearing phenanthroline derivatives as ligands: Cytotoxicity and DNA interaction evaluation
| Autor: | Fillipe V. Rocha, Gabriela Pintar de Oliveira, Moacir Rossi Forim, Mauro A. Lima, Renan D. Zanetti, João H. Araujo-Neto, Luciano da Silva Pinto, Eduardo E. Castellano, Josias S. Rocha, Adelino Vieira de Godoy Netto, George Bueno Santana Pereira |
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| Přispěvatelé: | Universidade Federal de São Carlos (UFSCar), Universidade Estadual Paulista (UNESP), Universidade de São Paulo (USP) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nitrile
ANTINEOPLÁSICOS Ligand Phenanthroline Electrospray ionization Cytotoxicity Molar conductivity Infrared spectroscopy 02 engineering and technology Phenanthroline derivatives 010402 general chemistry 021001 nanoscience & nanotechnology Furazan 01 natural sciences 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound Complexes of silver(I) chemistry Materials Chemistry Physical and Theoretical Chemistry 0210 nano-technology DNA interactions Nuclear chemistry |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Made available in DSpace on 2022-04-29T08:30:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01 In this work, three new silver(I) complexes, [Ag(NO2-NN)(tu)]NO3 (1), [Ag(NON-NN)(tu)]NO3 (2), and [Ag(CN-NN)(tu)]NO3 (3) and (R-N'N”= extended phenanthroline ligand with aromatic diamines replaced with R = NO2; NON (furazan); CN (nitrile); tu = thiourea) were synthesized and fully characterized by the techniques of UV–Vis spectroscopy; Infrared spectroscopy; 1H and 13C{1H} NMR; molar conductivity; elemental analysis (CHN); high-resolution electrospray ionization mass spectrometry (HRMS-ESI); and X-ray diffraction (compound 3). The compounds showed themselves to be stable to light, air, and the DMSO solution. The DNA interaction assays indicated that compounds 2 and 3 interacted with the DNA, by interaction via the minor groove. Compounds 2 and 3 showed outstanding cytotoxicity towards the human cell lines A2780cis (cisplatin-resistant ovarian carcinoma), the DU-145 (prostate cancer) cells, and MRC-5 (human lung fibroblasts). The IC50 (concentration of a compound that is required for 50% inhibition of the cell viability, in vitro) values substantially overcome that of cisplatin. This data has suggested that such a molecular design is promising to develop silver(I) complexes, with high anticancer activities. Departamento de Química Univ. Federal de São Carlos UNESP – Univ. Estadual Paulista Instituto de Química Departamento de Química Analítica Físico-Química e Inorgânica Instituto de Física de São Carlos Universidade de São Paulo Avenida Trabalhador São-Carlense 400 UNESP – Univ. Estadual Paulista Instituto de Química Departamento de Química Analítica Físico-Química e Inorgânica |
| Databáze: | OpenAIRE |
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