Hierarchical prediction errors in midbrain and septum during social learning
| Autor: | Klaas E. Stephan, Christoph Mathys, Andreea O. Diaconescu, Jan Mauer, Lars Kasper, Lilian A.E. Weber |
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| Přispěvatelé: | University of Zurich, Diaconescu, A O |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Culture Bayesian inference Inference Intention 170 Ethics 0302 clinical medicine Mesencephalon Theory of mind media_common Brain Mapping medicine.diagnostic_test Dopaminergic fMRI General Medicine Hierarchical prediction errors dopamine COMT Magnetic Resonance Imaging medicine.anatomical_structure Septum Pellucidum Psychology Cognitive psychology Adult 2805 Cognitive Neuroscience Tyrosine 3-Monooxygenase Cognitive Neuroscience media_common.quotation_subject hierarchical prediction errors theory of mind Fidelity 610 Medicine & health Experimental and Cognitive Psychology Catechol O-Methyltransferase Polymorphism Single Nucleotide Young Adult 03 medical and health sciences medicine Humans 10237 Institute of Biomedical Engineering Motivation 3205 Experimental and Cognitive Psychology Ventral striatum Original Articles Social learning Social Learning Settore M-PSI/02 - Psicobiologia e Psicologia Fisiologica 030104 developmental biology Functional magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | Social Cognitive and Affective Neuroscience, 12 (4) Social Cognitive and Affective Neuroscience |
| ISSN: | 1749-5016 1749-5024 |
| DOI: | 10.3929/ethz-b-000124291 |
| Popis: | Social learning is fundamental to human interactions, yet its computational and physiological mechanisms are not well understood. One prominent open question concerns the role of neuromodulatory transmitters. We combined fMRI, computational modelling and genetics to address this question in two separate samples (N = 35, N = 47). Participants played a game requiring inference on an adviser’s intentions whose motivation to help or mislead changed over time. Our analyses suggest that hierarchically structured belief updates about current advice validity and the adviser’s trustworthiness, respectively, depend on different neuromodulatory systems. Low-level prediction errors (PEs) about advice accuracy not only activated regions known to support ‘theory of mind’, but also the dopaminergic midbrain. Furthermore, PE responses in ventral striatum were influenced by the Met/Val polymorphism of the Catechol-O-Methyltransferase (COMT) gene. By contrast, high-level PEs (‘expected uncertainty’) about the adviser’s fidelity activated the cholinergic septum. These findings, replicated in both samples, have important implications: They suggest that social learning rests on hierarchically related PEs encoded by midbrain and septum activity, respectively, in the same manner as other forms of learning under volatility. Furthermore, these hierarchical PEs may be broadcast by dopaminergic and cholinergic projections to induce plasticity specifically in cortical areas known to represent beliefs about others. Social Cognitive and Affective Neuroscience, 12 (4) ISSN:1749-5016 ISSN:1749-5024 |
| Databáze: | OpenAIRE |
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