Tumor seeding following stereotactic biopsy of brain metastases
| Autor: | Bengt Karlsson, Kaj Ericson, Per Grane, Lars Kihlström |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Stereotactic biopsy Biopsy medicine.medical_treatment Radiosurgery Tumor seeding Metastasis Stereotaxic Techniques Central nervous system disease medicine Humans Aged medicine.diagnostic_test Brain Neoplasms business.industry medicine.disease Magnetic Resonance Imaging Kidney Neoplasms Female Tomography X-Ray Computed business Nuclear medicine Complication Brain metastasis |
| Zdroj: | Journal of Neurosurgery. 87:327-330 |
| ISSN: | 0022-3085 |
| DOI: | 10.3171/jns.1997.87.2.0327 |
| Popis: | ✓ In a series of 22 patients treated with gamma knife surgery for brain metastasis in whom biopsy specimens were obtained via stereotactically guided procedures before the radiosurgical treatment was administered, two cases with evidence of tumor seeding were observed on subsequent follow-up examination. These findings contradict the opinion that the risk for tumor spread after a biopsy is negligible. This evidence may be explained by the fact that radiosurgery leaves the surrounding tissue unaffected by the treatment, which results in preserved anatomy around the tumor. This allows the surgeon to define the previous biopsy channel and, consequently, whether a distant tumor recurrence may have resulted from tumor seeding related to the biopsy procedure. Additionally, radiosurgical treatment leaves tumor cells that may have been spread as a result of the biopsy unaffected, giving them the potential to divide and develop into a new tumor. In contrast to this, microsurgical removal of the tumor will affect the surrounding tissue, making it impossible to detect whether new metastases are resulting from seeding. Furthermore, conventional fractionated radiation therapy will sterilize tumor cells that may have spread, thus making it impossible for these cells to regrow.The authors conclude that the risk for tumor seeding following a stereotactically guided biopsy may be higher than previously assumed. |
| Databáze: | OpenAIRE |
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