A case of anti-SRP antibody-positive immune-mediated necrotizing myopathy triggered by human parvovirus B19 infection

Autor:	Iku, Suzuki, Ryohei, Nakao, Yuki, Unai, Yoshimichi, Miyazaki
Rok vydání:	2022
Předmět:	Adult Muscular Diseases Myositis Erythema Infectiosum Humans Female Neurology (clinical) Muscle Skeletal Signal Recognition Particle Autoantibodies Autoimmune Diseases
Zdroj:	Rinsho Shinkeigaku. 62:363-368
ISSN:	1882-0654 0009-918X
DOI:	10.5692/clinicalneurol.cn-001684
Popis:	We have reported a case of a 44-year-old woman with anti-signal recognition particle (SRP) antibody-positive immune-mediated necrotizing myopathy triggered by human parvovirus B19 (PVB19) infection. She was admitted to the hospital because of lower leg edema and muscle weakness after erythema infectiosum. Magnetic resonance imaging of the lower extremities revealed high signals in the proximal muscles and subcutaneous edema on STIR. Muscle biopsy showed myofiber regenerative changes and variation in fiber size. A myositis-specific autoantibody profile indicated a positive result for anti-SRP antibodies. We diagnosed the patient with immune-mediated necrotizing myopathy (IMNM). Muscle strength and subcutaneous edema improved gradually in 3 months following immunotherapy. This is the first case report of an IMNM associated with PVB19 infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1da84888d226909af7168dd1dfae6cd https://doi.org/10.5692/clinicalneurol.cn-001684 Zobrazit plný text záznamu