Repeated Cold Stress Enhances the Acute Restraint Stress-Induced Hyperthermia in Mice
| Autor: | Nanako Sugimoto, Seiji Ichida, Haruka Saeki, Yoshinori Funakami, Maho Tsubota, Tomoyoshi Miyamoto, Atsufumi Kawabata, Ai Nomura, Erika Kawashita |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Hyperthermia Male Restraint Physical medicine.medical_specialty Fever medicine.drug_class Pharmaceutical Science Anxiolytic Propanolamines 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Receptors Glucocorticoid Adipose Tissue Brown Corticosterone Stress Physiological Internal medicine Brown adipose tissue medicine Animals Uncoupling Protein 1 Pharmacology Diazepam business.industry Antagonist General Medicine medicine.disease Cold Temperature Mifepristone 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Anti-Anxiety Agents Anesthesia Adrenergic beta-3 Receptor Antagonists business Thermogenesis 030217 neurology & neurosurgery Glucocorticoid Stress Psychological medicine.drug |
| Zdroj: | Biologicalpharmaceutical bulletin. 40(1) |
| ISSN: | 1347-5215 |
| Popis: | The rodents exposed to repeated cold stress according to a specific schedule, known as specific alternation of rhythm in temperature (SART), exhibit autonomic imbalance, and is now used as an experimental model of fibromyalgia. To explore the susceptibility of SART-stressed animals to novel acute stress, we tested whether exposure of mice to SART stress for 1 week alters the extent of acute restraint stress-induced hyperthermia. Mice were subjected to 7-d SART stress sessions; i.e., the mice were alternately exposed to 24 and 4°C at 1-h intervals during the daytime (09:00-16:00) and kept at 4°C overnight (16:00-09:00). SART-stressed and unstressed mice were exposed to acute restraint stress for 20-60 min, during which rectal temperature was monitored. Serum corticosterone levels were measured before and after 60-min exposure to restraint stress. SART stress itself did not alter the body temperature or serum corticosterone levels in mice. Acute restraint stress increased the body temperature and serum corticosterone levels, both responses being greater in SART-stressed mice than unstressed mice. The enhanced hyperthermic responses to acute restraint stress in SART-stressed mice were significantly attenuated by SR59230A, a β3 adrenoceptor antagonist, but unaffected by diazepam, an anxiolytic, mifepristone, a glucocorticoid receptor antagonist, or indomethacin, a cyclooxygenase inhibitor. These results suggest that SART stress enhances the susceptibility of mice to acute restraint stress, characterized by increased hyperthermia and corticosterone secretion, and that the increased hyperthermic responses to acute stress might involve accelerated activation of sympathetic β3 adrenoceptors, known to regulate non-shivering thermogenesis in the brown adipose tissue. |
| Databáze: | OpenAIRE |
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