Molecular diversity of Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in Sri Lanka
| Autor: | Tommie C. Victor, U S Rajapaksa, S.M.P. Senevirathne, Robin M. Warren, A. J. Perera |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Veterinary medicine medicine.medical_specialty Tuberculosis Adolescent Oligonucleotides Mycobacterium tuberculosis Pulmonary tuberculosis Tuberculosis Multidrug-Resistant Epidemiology Humans Medicine Tuberculosis Pulmonary Sri Lanka Genetic diversity biology Molecular epidemiology business.industry Strain (biology) Public Health Environmental and Occupational Health General Medicine Middle Aged biology.organism_classification medicine.disease Bacterial Typing Techniques Infectious Diseases Immunology Female Parasitology Sri lanka business |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 102:997-1002 |
| ISSN: | 0035-9203 |
| DOI: | 10.1016/j.trstmh.2008.04.025 |
| Popis: | The strain diversity of 100 Mycobacterium tuberculosis isolates collected over a period of 18 months from tuberculosis (TB) cases in Sri Lanka was studied by spoligotyping. When compared to the international spoligotyping database, 43 spoligotype patterns were identified, of which 20 were previously described. The majority of isolates (72.45%) were clustered into major genetic group 1, and the most common spoligotype pattern belonged to the Beijing (ST1) strain family. All the Beijing strain isolates belonged to more recently evolved sublineages of M. tuberculosis. The characterization of Sri Lankan M. tuberculosis isolates by spoligotyping shows a heterogeneous pattern. The physical separation from the main Indian peninsula may be responsible for the different patterns observed between the two countries. An in-depth field study is needed to understand the spread and the true epidemiology of this infection. |
| Databáze: | OpenAIRE |
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