Aspergillus Mediastinitis after Orthotopic Heart Transplantation: A Case Report
| Autor: | Magdy M. El-Sayed Ahmed, Muhammad Aftab, Hari R. Mallidi, O.H. Frazier, Abdelkader Almanfi, Steve K. Singh |
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| Rok vydání: | 2015 |
| Předmět: |
Reoperation
medicine.medical_specialty Posaconazole Antifungal Agents Time Factors medicine.medical_treatment Case Reports Aspergillosis Drug Administration Schedule Surgical Flaps Amphotericin B medicine Humans Surgical Wound Infection Heart transplantation Voriconazole Aspergillus calidoustus Ischemic cardiomyopathy business.industry Middle Aged Triazoles medicine.disease Mediastinitis Combined Modality Therapy Surgery Aspergillus Treatment Outcome Debridement Anesthesia Ventricular assist device Drainage Heart Transplantation Drug Therapy Combination Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Texas Heart Institute journal. 42(5) |
| ISSN: | 1526-6702 |
| Popis: | A 55-year-old woman was admitted for orthotopic heart transplantation. Her medical history was notable for multiple cardiovascular problems, including ischemic cardiomyopathy that necessitated circulatory support with a left ventricular assist device. Five weeks after undergoing orthotopic heart transplantation, she developed Aspergillus calidoustus mediastinitis, for which she underwent a prolonged course of antifungal treatment that comprised (in sequence) posaconazole for 11 days, voriconazole for 10 days, and amphotericin B for 42 days. During this period, she also underwent repeated mediastinal drainage and sternal débridement, followed by sternal wiring and coverage with bilateral pectoralis advancement flaps. Four months postoperatively, she was discharged from the hospital with a successfully controlled infection and a healed sternum. To our knowledge, only 3 previous cases of Aspergillus mediastinitis after orthotopic heart transplantation have been reported in the literature, none of which was Aspergillus calidoustus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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