Intensive longitudinal characterization of multidimensional biobehavioral dynamics in laboratory rats
| Autor: | Ekaterina Mitricheva, Hamid R. Noori, Mehrdad Hasanpour, Nikos K. Logothetis |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Aging QH301-705.5 Longitudinal data Biology Locomotor activity General Biochemistry Genetics and Molecular Biology rat behavior Rats Sprague-Dawley 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Rhythm Cognition Confined Spaces Sex Factors Species Specificity state transitions Animals Rats Long-Evans Biology (General) Rats Wistar automatic biobehavioral monitoring circatidal rhythms Tidal Waves Circadian Rhythm Rats 030104 developmental biology social interactions Female Neuroscience 030217 neurology & neurosurgery Locomotion |
| Zdroj: | Cell Reports, Vol 35, Iss 2, Pp 108987-(2021) Cell Reports |
| ISSN: | 2211-1247 |
| Popis: | Summary Rats have been used as animal models for human diseases for more than a century, yet a systematic understanding of basal biobehavioral phenotypes of laboratory rats is still missing. In this study, we utilize wireless tracking technology and videography, collect and analyze more than 130 billion data points to fill this gap, and characterize the evolution of behavior and physiology of group-housed male and female rats (n = 114) of the most commonly used strains (Lister Hooded, Long-Evans, Sprague-Dawley, and Wistar) throughout their development. The resulting intensive longitudinal data suggest the existence of strain and sex differences and bi-stable developmental states. Under standard laboratory 12-h light/12-h dark conditions, our study found the presence of multiple oscillations such as circatidal-like rhythms in locomotor activity. The overall findings further suggest that frequent movement along cage walls or thigmotaxic activity may be a physical feature of motion in constrained spaces, critically affecting the interpretation of basal behavior of rats in cages. |
| Databáze: | OpenAIRE |
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