Flinderoles A−C: Antimalarial Bis-indole Alkaloids from Flindersia Species
| Autor: | Yunjiang Feng, Anthony R. Carroll, Liza Fernandez, Vicky M. Avery, Ronald J. Quinn, Malcolm Stewart Buchanan |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Borreverine
Indole test Magnetic Resonance Spectroscopy Natural product biology Stereochemistry Organic Chemistry Drug Evaluation Preclinical Papua New Guinean biology.organism_classification Biochemistry Medicinal chemistry Indole Alkaloids Flindersia Antimalarials Inhibitory Concentration 50 chemistry.chemical_compound Flindersia acuminata chemistry Animals Parasites Bis indole Physical and Theoretical Chemistry Rutaceae |
| Zdroj: | Organic Letters. 11:329-332 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol802506n |
| Popis: | With the aim of finding new natural product antimalarials, the novel indole alkaloids flinderole A-C were found to have selective antimalarial activities with IC(50) values between 0.15-1.42 microM. Flinderole A was isolated from the Australian plant Flindersia acuminata and flinderoles B and C from the Papua New Guinean plant F. amboinensis. Flinderoles A-C contain an unprecedented rearranged skeleton compared to their related isomers of the borreverine class of compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|