Male fertility in factor XIII deficiency
| Autor: | Moshe Frydman, Eliahu Braude, Draga Creter, Rina Zamir, Batsheva Bonne-Tamir |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Genetic Markers
Male medicine.medical_specialty Physiology Male infertility Consanguinity Internal medicine medicine Humans Factor XIII deficiency Genetic heterogeneity business.industry Homozygote Obstetrics and Gynecology Factor XIII medicine.disease Factor XIII Deficiency Pedigree Fertility Endocrinology Reproductive Medicine Male fertility Hemostasis Female business medicine.drug |
| Zdroj: | Fertility and Sterility. 45:729-731 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)49351-9 |
| Popis: | Seven homozygotes for F-XIII deficiency were found in a large inbred Israeli-Arab kindred. One affected woman had early abortions. Two affected men and one probably affected man had children, two of whom also were affected. Paternity was confirmed by segregation of HLAs and erythrocyte antigens and enzymes. This is the first documentation of normal male fertility in unequivocally affected patients. Clinical variability or genetic heterogeneity may account for previously reported male infertility. |
| Databáze: | OpenAIRE |
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