Comparison of Prognosis in Unrecognized Versus Recognized Myocardial Infarction in Men Versus Women > 55 Years of Age (from the Rotterdam Study)
| Autor: | Jan A. Kors, Jacqueline C.M. Witteman, Gerard van Herpen, Eric Boersma, Oscar H. Franco, Abbas Dehghan, Jaap W. Deckers, Abbas M Solouki, Albert Hofman, Maarten J.G. Leening, Jan Heeringa, M. Arfan Ikram |
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| Přispěvatelé: | Epidemiology, Cardiology, Medical Informatics, Radiology & Nuclear Medicine |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Urban Population Population Myocardial Infarction Rotterdam Study Electrocardiography Age Distribution Sex Factors medicine Humans Myocardial infarction Prospective Studies Sex Distribution education Prospective cohort study Aged Netherlands education.field_of_study business.industry Hazard ratio Age Factors Middle Aged medicine.disease Prognosis Confidence interval Survival Rate Population Surveillance Cohort Female Myocardial infarction diagnosis Morbidity Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | American Journal of Cardiology, 113(1), 1-6. Elsevier Inc. |
| ISSN: | 1879-1913 0002-9149 |
| Popis: | Unrecognized myocardial infarction (MI) is frequent in the general population. Its prognosis is reported to be at least as unpropitious as that of recognized MI, particularly in men. However, contemporary data with long follow-up are lacking. The aims of this study were to investigate the long-term prognosis of unrecognized MI with respect to all-cause and cause-specific mortality and to investigate possible differences in prognosis by gender. In the population-based Rotterdam Study (2,672 men and 3,862 women), the presence of unrecognized MI and recognized MI was determined at baseline (1990 to 1993). The cohort was followed for nearly 2 decades for all-cause and cause-specific mortality. During 82,268 patient-years of follow-up (median 15.6 years) 3,412 patients died (1,300 from cardiovascular causes). Men and women with recognized and unrecognized MIs had increased total mortality rates compared with those without MIs. Hazard ratios (HRs) for men and women were 1.57 (95% confidence interval [CI] 1.36 to 1.81) and 1.89 (95% CI 1.56 to 2.30) for recognized MI and 1.72 (95% CI 1.43 to 2.07) and 1.36(95% CI 1.14 to 1.61) for unrecognized MI. Unrecognized MI was associated with increased risks for cardiovascular mortality (men: HR 2.19, 95% CI 1.66 to 2.91; women: HR 1.36, 95% CI 1.03 to 1.81) and noncardiovascular mortality (men: HR 1.47, 95% CI 1.14 to 1.89; women: Ha 1.39, 95% CI 1.10 to 1.75). In conclusion, the long-term prognosis of patients with unrecognized MIs is worse compared with those without MIs and applies not only to cardiovascular mortality but also to noncardiovascular mortality. In men, the prognosis is as unfavorable as that of patients with recognized MIs. (C) 2014 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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