Dopamine antagonist antipsychotics in diverted forensic populations
| Autor: | Michael A Cummings, Ai-Li W Arias, George Proctor |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Psychosis
medicine.medical_specialty business.industry Dopamine antagonist Cognition Forensic Psychiatry medicine.disease Medication Adherence Psychiatry and Mental health Schizophrenia Dopamine Dopamine receptor D2 Plasma concentration Medicine Community setting Dopamine Antagonists Humans Schizophrenic Psychology Neurology (clinical) business Psychiatry medicine.drug Antipsychotic Agents |
| Zdroj: | CNS spectrums. 25(2) |
| ISSN: | 1092-8529 |
| Popis: | In community settings, negative symptoms and cognitive deficits are the primary barriers to independent living, stable relationships, and employment for individuals suffering from schizophrenia-spectrum disorders. In contrast, however, positive psychotic symptoms (e.g., command hallucinations and persecutory delusions) often drive behavior which serves as the gateway to arrest and criminalization. Historically, the keystone of treatment for positive psychotic symptoms has been antagonism of dopamine D2 receptors in the mesolimbic tract. In this article, we review and explore the principles underlying dopamine antagonism for the treatment of psychosis; optimization of dopamine antagonists in treating positive psychotic symptoms; the advantages of depot dopamine antagonist antipsychotics in forensic settings; the concepts of pharmacokinetic and pharmacodynamic treatment failures; and the role of medication plasma concentrations in optimizing and managing treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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