In vitro and in vivo effect of growth hormone on cytotoxic activity
| Autor: | Anice Valtorta, Mariangela Cisternino, Mauro Bozzola, Isabella Biscaldi, A. Moretta, Rose Marie Schimpff |
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| Rok vydání: | 1990 |
| Předmět: |
Cytotoxicity
Immunologic Male medicine.medical_specialty Adolescent Peripheral blood mononuclear cell Growth hormone deficiency Cell Line Immune system In vivo Internal medicine medicine Cytotoxic T cell Humans Insulin-Like Growth Factor I Child Killer Cells Lymphokine-Activated Growth Disorders business.industry medicine.disease Recombinant Proteins Killer Cells Natural Endocrinology Cell culture Hormone receptor Child Preschool Growth Hormone Pediatrics Perinatology and Child Health Female business Hormone |
| Zdroj: | The Journal of pediatrics. 117(4) |
| ISSN: | 0022-3476 |
| Popis: | The presence of specific growth hormone receptors on peripheral blood mononuclear cells 1-3 raises the possibility that GH may affect the immune system directly. Data obtained in a mouse model suggest that GH may infleunce cytotoxic activity mediated by natural killer cells, 4 which are lymphocytes involved in immune surveillance for viral infections and neoplastic diseases. 58 The effects of GH on cell-mediated cytotoxic activity in human subjects are still controversial. Impaired NK cell activity has been found in patients with GH deficiency. 91~ Although it has been reported that short-term administration of GH and GH-releasing hormone fails to normalize NK cell function in GH-deficient children, 9 a previous work demonstrated that daily exogenous GH treat~nent increases this activity in GH-deficient women. 1~ The aim of our work was to study NK cell-mediated cytotoxic activity in GH-deficient children before and during long-term therapy with biosynthetic GH. |
| Databáze: | OpenAIRE |
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