Blockade of Motor Cortical Long-Term Potentiation Induction by Glutamatergic Dysfunction Causes Abnormal Neurobehavior in an Experimental Subarachnoid Hemorrhage Model
Autor: | Minoru Fujiki, Kazuhiro Kuga, Yukari Kawasaki, Harushige Ozaki, Hirotaka Fudaba |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Subarachnoid hemorrhage subarachnoid hemorrhage Cognitive Neuroscience Long-Term Potentiation Neuroscience (miscellaneous) Stimulation lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience Glutamatergic neurobehavior 0302 clinical medicine motor-evoked potential Animals Medicine electrical stimulation lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research theta burst stimulation business.industry Interstimulus interval Antagonist Neural Inhibition Long-term potentiation Neurophysiology Evoked Potentials Motor medicine.disease Transcranial Magnetic Stimulation Sensory Systems Rats 030104 developmental biology medicine.anatomical_structure business Neuroscience 030217 neurology & neurosurgery Motor cortex |
Zdroj: | Frontiers in Neural Circuits Frontiers in Neural Circuits, Vol 15 (2021) |
ISSN: | 1662-5110 |
Popis: | Subarachnoid hemorrhage (SAH) is a life-threatening condition that can also lead to permanent paralysis. However, the mechanisms that underlying neurobehavioral deficits after SAH have not been fully elucidated. As theta burst stimulation (TBS) can induce long-term potentiation (LTP) in the motor cortex, we tested its potential as a functional evaluation tool after experimentally induced SAH. Motor cortical inter-neuronal excitability was evaluated in anesthetized rats after 200 Hz-quadripulse TBS (QTS5), 200 Hz-quadripulse stimulation (QPS5), and 400 Hz-octapulse stimulation (OPS2.5). Furthermore, correlation between motor cortical LTP and N-methyl-D-aspartate-receptor activation was evaluated using MK-801, a NMDA-receptor antagonist. We evaluated inhibition-facilitation configurations [interstimulus interval: 3 ms; short-latency intracortical inhibition (SICI) and 11 ms; intracortical facilitation (ICF)] with paired electrical stimulation protocols and the effect of TBS paradigm on continuous recording of motor-evoked potentials (MEPs) for quantitative parameters. SAH and MK-801 completely blocked ICF, while SICI was preserved. QTS5, QPS5, and OPS2.5 facilitated continuous MEPs, persisting for 180 min. Both SAH and MK-801 completely blocked MEP facilitations after QPS5 and OPS2.5, while MEP facilitations after QTS5 were preserved. Significant correlations were found among neurological scores and 3 ms-SICI rates, 11 ms-ICF rates, and MEP facilitation rates after 200 Hz-QTS5, 7 days after SAH (R2 = 0.6236; r = −0.79, R2 = 0.6053; r = −0.77 and R2 = 0.9071; r = 0.95, p < 0.05, respectively). Although these findings need to be verified in humans, our study demonstrates that the neurophysiological parameters 3 ms-SICI, 11 ms-ICF, and 200 Hz-QTS5-MEPs may be useful surrogate quantitative biomarkers for assessing inter-neuronal function after SAH. |
Databáze: | OpenAIRE |
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