Potentially toxic concentrations in blood of total ropivacaine after bilateral transversus abdominis plane blocks; a pharmacokinetic study
| Autor: | Jacob Rosenberg, Torben Breindahl, Ann Merete Møller, Henrik Torup, Anja U. Mitchell, Egon G. Hansen |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Lidocaine Denmark Injections Subcutaneous Blood Pressure Pharmacokinetics Humans Medicine Ropivacaine Prospective Studies Transversus abdominis Anesthetics Local Hospitals Teaching Ultrasonography Interventional Abdominal Muscles Aged Aged 80 and over business.industry Nerve Block Middle Aged Amides Anesthesiology and Pain Medicine Anesthesia Female Drug Monitoring Ultrasonography business medicine.drug |
| Zdroj: | European Journal of Anaesthesiology. 29:235-238 |
| ISSN: | 0265-0215 |
| DOI: | 10.1097/eja.0b013e328350b0d5 |
| Popis: | Elevated blood levels of lidocaine and ropivacaine have been described after transversus abdominis plane (TAP) block.To investigate the pharmacokinetic profile of ropivacaine after bilateral TAP blocks.Prospective observational pharmacokinetic study.University teaching hospital in Copenhagen, Denmark.Twenty-one adult patients presenting for abdominopelvic surgery with bilateral TAP blocks were enrolled.Ultrasound-guided TAP blocks with bilateral injections of 20 ml ropivacaine 0.5% w/v (total dose 200 mg). Blood was sampled at 0, 10, 30 and 60 min after TAP blocks.Total and free peak blood concentrations (Cmax) of ropivacaine.Data were analysed from N = 18 patients. The median dose of ropivacaine was 2.7 mg kg(-1) (range: 1.9-4.2 mg kg(-1)). Median total ropivacaine concentrations were 1.0, 1.6 and 1.7 μg ml(-1) at 10, 30 and 60 min, respectively. Six patients (33%) had Cmax values above 2.2 μg ml(-1) and the highest concentration measured was 5.1 μg ml(-1). One patient had a 33% drop in mean arterial blood pressure.TAP blocks with bilateral injections of 20 ml ropivacaine 0.5% w/v gave rise to potentially toxic peak blood concentrations of total ropivacaine in one-third of the patients. |
| Databáze: | OpenAIRE |
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