A Prospective OCT Study of Rubella Retinopathy
| Autor: | Abhijit Sinha Roy, Hemant Anaspure, Anand Vinekar, Jyoti Matalia, Shwetha Mangalesh, K Bhujang Shetty, Neha Anegondi |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
genetic structures 01 natural sciences Rubella 010309 optics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology 0103 physical sciences Medicine External limiting membrane Congenital rubella syndrome Retinal pigment epithelium medicine.diagnostic_test business.industry Fundus photography Retinal medicine.disease Rubella retinopathy eye diseases medicine.anatomical_structure chemistry 030221 ophthalmology & optometry sense organs Choroid business |
| Zdroj: | Ophthalmology Retina. 2:1235-1240 |
| ISSN: | 2468-6530 |
| Popis: | To analyze rubella retinopathy qualitatively and quantitatively in children diagnosed with congenital rubella syndrome (CRS) using a handheld spectral-domain (SD) OCT device.Prospective, cross-sectional, nonrandomized, comparative observational study in a tertiary eye care center in south India.Cases comprised 24 eyes of 13 children diagnosed with CRS based on seropositivity with rubella retinopathy. Controls comprised 26 eyes of 13 age-matched healthy children with normal retina.All participants underwent retinal imaging with RetCam fundus photography (Natus Medical Inc, Pleasanton, CA) and handheld SD OCT (Bioptigen, Inc., Durham, NC). The SD OCT images of both cases and controls were segmented. Retinal and choroid thickness parameters were computed.Qualitative and quantitative changes were observed in SD OCT images of rubella retinopathy compared with those from controls.Characteristic salt-and-pepper appearance was observed on fundus photography in children with rubella compared with the healthy children. The appearance of fovea and retinal features such as foveal dip, external limiting membrane, inner segment-outer segment boundary, outer segment-retinal pigment epithelium boundary, and retinal pigment epithelium were significantly different (P0.05) in eyes with rubella retinopathy compared with healthy eyes Furthermore, eyes with rubella retinopathy exhibited significantly reduced central foveal thickness (P = 0.025), subfoveal outer retinal thickness (P = 0.01), and subfoveal choroid thickness (P = 0.007) compared with healthy eyes.Distinct qualitative and quantitative differences were observed in the SD OCT images of eyes with rubella retinopathy compared with those from healthy eyes. |
| Databáze: | OpenAIRE |
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