Does the Presence of Endometriosis Affect Prognosis of Ovarian Cancer?
| Autor: | Thomas A. Caputo, Divya Gupta, Cathleen Matrai, Alain Pierre-Louis, Helen E. Dinkelspiel, Lora Hedrick Ellenson, Kevin Holcomb, Ya Lin Chiu, Sara J. Pauk |
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| Rok vydání: | 2016 |
| Předmět: |
Cancer Research
medicine.medical_specialty Younger age Endometriosis Kaplan-Meier Estimate Carcinoma Ovarian Epithelial Gastroenterology Disease-Free Survival Article 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology medicine Humans Neoplasms Glandular and Epithelial Stage (cooking) Pelvis Aged Proportional Hazards Models Ovarian Neoplasms Gynecology Lower grade 030219 obstetrics & reproductive medicine business.industry General Medicine Middle Aged Prognosis medicine.disease medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Female business Ovarian cancer |
| Zdroj: | Cancer Investigation. 34:148-154 |
| ISSN: | 1532-4192 0735-7907 |
| DOI: | 10.3109/07357907.2016.1139716 |
| Popis: | Ovarian cancers diagnosed between 2000 and 2013 were examined and cases with and without endometriosis compared. Among 139 epithelial ovarian, there were 49 (35%) with endometriosis and 90 (65%) without endometriosis. Endometriosis associated ovarian cancers were more likely to be confined to the pelvis (54% vs. 9%, p < 0.0001) and lower grade (51% vs. 29%, p = 0.014). Younger age and earlier stage independently predicted the presence of endometriosis (p = 0.0011 and p < 0.0001, respectively). Ovarian cancer patients with endometriosis had improved PFS and OS [(HR = 0.20; 95% CI, 0.09-0.43), (HR = 0.18; 95% CI, 0.04-0.81)], compared to patients without endometriosis; however, endometriosis had no independent prognostic significance. |
| Databáze: | OpenAIRE |
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