Cutaneous adverse drug reactions with fixed-dose combinations: Special reference to self-medication and preventability
| Autor: | Swayam Sourav Sahoo, Sibasis Patro, Ratikanta Tripathy, Kali Prasad Pattnaik, Srikanta Mohanty, Suhasini Dehury, Prasanjeet Mohanty |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions media_common.quotation_subject Fixed-dose combination Self Medication 030226 pharmacology & pharmacy Fixed dose 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine preventability Internal medicine Medicine Humans Pharmacology (medical) 030212 general & internal medicine Drug reaction Prospective Studies Practice Patterns Physicians' fixed dose combination media_common Pharmacology Nonsteroidal business.industry Cutaneous adverse drug reactions self-medication Drug Combinations chemistry Drug Eruptions business Self-medication Research Article |
| Zdroj: | Indian Journal of Pharmacology |
| ISSN: | 1998-3751 |
| Popis: | OBJECTIVES: To identify the association of cutaneous adverse drug reactions (CADRs) with use of fixed-dose combinations (FDCs) and to compare the occurrence of preventable CADRs between self-medication and prescribed medication of FDCs. PATIENTS AND METHODS: All cases of suspected CADRs with the use of FDCs were collected, and causality assessment was carried out using the WHO UMC scale. The burden of CADRs on self-medication and prescribed medication was found out. Preventability status was analyzed by Schumock and Thornton Criteria and compared between self-medication and prescribed medication. RESULTS: A total of 74 CADRs were detected; 68.91% were detected with antimicrobial and 31.09% with nonsteroidal anti-inflammatory drug-based FDCs. Fluoroquinolones + nitroimidazole was the most commonly suspected medications. Majority of CADRs (44.59%) were fixed-drug eruptions, which was significantly higher than others (P = 0.002). Analysis of preventability showed that there was a significantly higher occurrence of definitely preventable CADRs in self-medication group (40%) in comparison to prescribed group (6.81%), P = 0.028. CONCLUSIONS: Self-medication with FDCs is quite common and associated with a higher rate of preventable CADRs in comparison to that in prescribed medication. |
| Databáze: | OpenAIRE |
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