Elevated doses of carmustine and mitomycin C, with lonidamine enhancement and autologous bone marrow transplantation in the treatment of advanced colorectal cancer: Results from a pilot study
| Autor: | Giulio Gualdi, Fabrizio Franchi, V. Pagani Guazzugli Bonaiuti, Patrizia Seminara, G. Codacci Pisanelli, F. Giovagnorio |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Indazoles Colorectal cancer Mitomycin medicine.medical_treatment Antineoplastic Agents Pilot Projects Drug Administration Schedule chemistry.chemical_compound Therapeutic index Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Bone Marrow Transplantation Chemotherapy Carmustine Rectal Neoplasms business.industry Mitomycin C Lonidamine Middle Aged medicine.disease Combined Modality Therapy Survival Analysis Surgery Regimen medicine.anatomical_structure chemistry Colonic Neoplasms Female Bone marrow business medicine.drug |
| Zdroj: | European Journal of Cancer. 30:1420-1423 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/0959-8049(93)e0161-i |
| Popis: | 10 patients with advanced colorectal cancer were treated with elevated doses of carmustine and mitomycin C. The regimen was potentiated by lonidamine and supported by autologous bone marrow transplantation. The results of this pilot study were encouraging, with a response rate of 50% and a significantly better survival for responders versus non-responders. No appreciable toxicity of the therapy was observed. This aspect, together with the simplicity of the procedure, calls for further investigations to confirm the good therapeutic index of the treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|