Mixed Type of Malignant Mesothelioma in an Aged Male ICR Mouse
Autor: | Makoto Shirai, Tomoe Tanimoto, Takanori Maejima, Kazuyoshi Kumagai, Toshihiko Makino, Atsushi Sanbuissho, Munehiro Teranishi, Kiyonori Kai |
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Jazyk: | angličtina |
Rok vydání: | 2011 |
Předmět: |
Pathology
medicine.medical_specialty thoracic cavity biology Thoracic cavity business.industry Mixed type Vimentin Case Report ICR Toxicology medicine.disease Pathology and Forensic Medicine Staining Cytokeratin medicine.anatomical_structure mesothelioma medicine Mitotic Figure biology.protein Immunohistochemistry Mesothelioma mixed type business mouse |
Zdroj: | Journal of Toxicologic Pathology |
ISSN: | 1881-915X 0914-9198 |
Popis: | Multiple whitish nodules in the thoracic cavity at the site of the thymus were observed in a 101-week-old male ICR mouse. In a histopathological examination, the neoplastic cells were predominantly fusiform in shape and proliferated in sarcomatoid growth patterns. Some neoplastic cells showed epithelial growth patterns, such as the ductal structures. Mitotic figures were frequently seen, and small necrotic foci and invasion to adjacent thoracic organs were noted. In Alcian blue staining, bluish materials were observed between fusiform-shaped cells and in some of the lumens of the ductal structures. In immunohistochemistry, both fusiform-shaped and ductal structure-forming cells were positive for vimentin and weakly positive to positive for cytokeratin. Based on the aforementioned findings, the thoracic nodules were diagnosed as a mixed type of malignant mesothelioma. This case was thought to be rare because of the very low occurrence of spontaneous mesothelioma in mice. |
Databáze: | OpenAIRE |
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