The oncofetal protein IMP3: a useful marker to predict poor clinical outcome in neuroendocrine tumors of the lung
| Autor: | Gaetano Bulfamante, Stefano Fiori, Dario Ricca, Alessandro Palleschi, Silvano Bosari, Stefano Ferrero, Elena Guerini Rocco, Valentina Vaira, Alessandro Del Gobbo |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Homeobox protein NANOG Adult Male Pathology medicine.medical_specialty Lung Neoplasms Cell Neuroendocrine tumors Stem cell marker Nanog Disease-Free Survival Young Adult medicine Biomarkers Tumor Humans Lung cancer Aged Aged 80 and over Lung Lung neuroendocrine tumors IMP3 business.industry Large cell RNA-Binding Proteins Middle Aged medicine.disease Immunohistochemistry Survival Analysis Oct3/4 Neuroendocrine Tumors medicine.anatomical_structure Treatment Outcome Oncology Female Stem cell business |
| Zdroj: | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 9(11) |
| ISSN: | 1556-1380 |
| Popis: | Introduction: We evaluated the expression of the oncofetal protein IMP3 in a series of neuroendocrine tumors of the lung, correlating our results with proliferating index Ki67 and with the expression of the two most studied stem cell markers in lung cancer, Nanog and Oct3/4. Methods: A total of 74 patients with a diagnosis of neuroendocrine tumor including 46 cases of typical carcinoid, nine cases of atypical carcinoids, 13 cases of large cell neuroendocrine carcinomas and six cases of small cell carcinomas were enrolled. Results: IMP3 was expressed in 50% of small cell carcinomas, 84% of large cell neuroendocrine carcinomas, 55% of atypical carcinoids and 10% of typical carcinoids. IMP3-positive cases showed signifi- cantly decreased overall and disease-free survival time compared with IMP3-negative cases. Nanog was expressed in 50% of small cell carcinomas, 31% of large cell neuroendocrine carcinomas, 33% of atypical carcinoids and 15% of typical carcinoids, and 68% of IMP3- positive tumors were also enriched for Nanog expression. Conversely, Oct3/4 expression could not be detected in all the analyzed series. When combining Ki67 and IMP3 expression we demonstrated that all the cases with a Ki67 index higher than 4% were also IMP3-positive, and their simultaneous expression was a poor prognostic factor. Conclusions: IMP3 is a marker of poor outcome in lung neuroen- docrine tumors; its correlation with Nanog expression suggest an implication of IMP3 in stem cell processes and its association with a Ki67 labeling index higher than 4% stratifies a subset of atypical carcinoids with a higher risk of recurrence and mortality. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|