Chronic interstitial pneumonia in young patients undergoing lung transplantation or autopsy: clinico-radiologic-pathologic observations from a single institution
| Autor: | Hidehiro Hayashi, Susumu Kanazawa, Toshihiro Iguchi, Ichiro Yamadori, Mayu Uka, Shuhei Sato, Toshiharu Mitsuhashi, Takahiro Oto, Katsuya Kato |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty High-resolution computed tomography Pathology Adolescent medicine.medical_treatment Autopsy 030204 cardiovascular system & hematology Ground-glass opacity Diagnosis Differential Young Adult 03 medical and health sciences Idiopathic pulmonary fibrosis 0302 clinical medicine Usual interstitial pneumonia Humans Medicine Lung transplantation Radiology Nuclear Medicine and imaging Idiopathic Interstitial Pneumonias Lung Idiopathic interstitial pneumonia Retrospective Studies medicine.diagnostic_test business.industry Middle Aged respiratory system medicine.disease respiratory tract diseases medicine.anatomical_structure 030228 respiratory system Chronic Disease Female Radiology medicine.symptom Tomography X-Ray Computed business Lung Transplantation |
| Zdroj: | Japanese Journal of Radiology. 34:515-522 |
| ISSN: | 1867-108X 1867-1071 |
| DOI: | 10.1007/s11604-016-0551-5 |
| Popis: | To retrospectively evaluate high-resolution computed tomography (HRCT) findings and clinical diagnoses of chronic interstitial pneumonia (IP) with a poor prognosis in young patients (≤50 years). HRCT images of 8 men and 7 women (mean age 34.8 years) obtained before lung transplantation or autopsy were reviewed. After reviewing whole lung specimens and pathologic diagnoses, all patients were clinically diagnosed according to the 2010 idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP) consensus statement. HRCT images revealed intralobular reticular opacity, air cysts, ground glass opacity, traction bronchiectasis, and interlobular septal thickening. Intralobular reticular opacity was the most extensive finding. Abnormal findings existed predominantly in both the peripheral and lower lung zones in only 1 patient. Classifications of HRCT patterns were “UIP” (n = 2), “inconsistent with UIP” (n = 11), and “indeterminate UIP” (n = 2). Multidisciplinary diagnoses were “IPF/UIP” (n = 1), “possible IPF/UIP” (n = 1), “IP with connective tissue disease” (n = 7), “fibrotic nonspecific IP” (n = 1), and “unclassified IP” (n = 5). The most extensive HRCT finding was intralobular reticular opacity. Most HRCT images differed from typical IPF/UIP, and IPF/UIP was uncommon in young patients with chronic IP with a poor prognosis. |
| Databáze: | OpenAIRE |
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