AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues
| Autor: | Ruxing Xi, Xiaozhi Zhang, Yu-Wei Chang, Xin Chen, Jia Guo, Xuanwei Zhang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Human glioma
business.industry General Medicine medicine.disease General Biochemistry Genetics and Molecular Biology Protein expression radioresistance medicine.anatomical_structure Cytoplasm Glioma Radioresistance glioma Immunology immunohistochemistry Cancer research Medicine Immunohistochemistry Research-Article business AEG-1 Astrocyte Glioblastoma |
| Zdroj: | Journal of Biomedical Research |
| ISSN: | 1674-8301 |
| Popis: | Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r = 0.227, P = 0.045), clinical stage (r = 0.491, P0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r = 0.240, P = 0.035) and PPP6c (r = 0.250, P = 0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance. |
| Databáze: | OpenAIRE |
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