Os agentes clareadores dentais podem causar genotoxicidade no epitélio oral? Uma revisão sistemática com metanálise
| Autor: | Wilton Takeshita, Liciane Dos Santos Menezes, Patricia Leite-Ribeiro |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Mutagenicity test
Mouth Genotoxicidade Tooth bleaching agents Oral mucosa absorption Boca Teste de mutagenicidade Absorção pela mucosa oral Genotoxicidad Blanqueadores dentales General Earth and Planetary Sciences Genotoxicity Pruebas de Mutagenicidad Clareadores dentais Absorción por la mucosa bucal General Environmental Science |
| Zdroj: | Research, Society and Development; Vol. 11 No. 1; e11411124928 Research, Society and Development; Vol. 11 Núm. 1; e11411124928 Research, Society and Development; v. 11 n. 1; e11411124928 Research, Society and Development Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
| ISSN: | 2525-3409 |
| Popis: | Objective: To assess, with a systematic review (SR) with meta-analysis, the occurrence of genotoxic effects on the oral epithelium after exposure to tooth bleaching agents. Material and methods: This review was performed according to the PRISMA protocols. To identify relevant studies, a systematic search was performed in the following electronic databases: PubMed, Scopus, Embase, LILACS, and Google Scholar. The research question was "Can tooth bleaching agents cause genotoxicity in the oral epithelium?”. The treatment effects were defined as the standardized mean difference (SMD) and 95% confidence intervals (CI) were established. Results: 154 studies were selected and, after screening titles and abstracts, seven full-text manuscripts were assessed for eligibility, of which four studies were included in the meta-analysis. There were no statistically significant differences in the frequency of micronuclei before and after exposure (SMD= -0.14, 95% CI, 0.98 to 0.60, p=0.74), with a Tau2 index = 1.00; Chi2 = 70.20; p-value |
| Databáze: | OpenAIRE |
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