Adaptation of Brain Functional and Structural Networks in Aging
| Autor: | Ta Anh Tuan, Anqi Qiu, Shen-Hsing Annabel Chen, Annie Lee, Nagulan Ratnarajah |
|---|---|
| Přispěvatelé: | Liu, Yong, School of Humanities and Social Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Science::Biological sciences::Human anatomy and physiology::Neurobiology [DRNTU]
Adult Male Models Anatomic Aging Models Neurological lcsh:Medicine Prefrontal Cortex Biology Brain mapping Temporal lobe Young Adult medicine Aging brain Humans Prefrontal cortex lcsh:Science Aged Aged 80 and over Brain Mapping Multidisciplinary medicine.diagnostic_test Brain morphometry lcsh:R Brain Human brain Middle Aged Adaptation Physiological Magnetic Resonance Imaging Temporal Lobe medicine.anatomical_structure nervous system lcsh:Q Female Nerve Net Occipital lobe Functional magnetic resonance imaging Neuroscience Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 4, p e0123462 (2015) |
| ISSN: | 1932-6203 |
| Popis: | The human brain, especially the prefrontal cortex (PFC), is functionally and anatomically reorganized in order to adapt to neuronal challenges in aging. This study employed structural MRI, resting-state fMRI (rs-fMRI), and high angular resolution diffusion imaging (HARDI), and examined the functional and structural reorganization of the PFC in aging using a Chinese sample of 173 subjects aged from 21 years and above. We found age-related increases in the structural connectivity between the PFC and posterior brain regions. Such findings were partially mediated by age-related increases in the structural connectivity of the occipital lobe within the posterior brain. Based on our findings, it is thought that the PFC reorganization in aging could be partly due to the adaptation to age-related changes in the structural reorganization of the posterior brain. This thus supports the idea derived from task-based fMRI that the PFC reorganization in aging may be adapted to the need of compensation for resolving less distinctive stimulus information from the posterior brain regions. In addition, we found that the structural connectivity of the PFC with the temporal lobe was fully mediated by the temporal cortical thickness, suggesting that the brain morphology plays an important role in the functional and structural reorganization with aging. Published version |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|