Prognostic Impact of Lymph Node Excision in T1 and T2 Gallbladder Cancer: a Population-Based and Propensity Score-Matched SEER Analysis
| Autor: | Thomas Steffen, Bernhard Widmann, Ignazio Tarantino, Sabrina M. Ebinger |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 030230 surgery Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Surveillance Epidemiology and End Results Medicine Humans Gallbladder cancer Propensity Score Lymph node Neoplasm Staging Retrospective Studies business.industry Proportional hazards model Hazard ratio Retrospective cohort study medicine.disease Prognosis Confidence interval medicine.anatomical_structure 030220 oncology & carcinogenesis Lymph Node Excision Surgery Lymphadenectomy Gallbladder Neoplasms Lymph Nodes business |
| Zdroj: | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 24(3) |
| ISSN: | 1873-4626 |
| Popis: | The aim of this study was to assess the effect of lymphadenectomy on survival in T1/T2 gallbladder cancer (GBC). In this retrospective cohort study, patients undergoing surgery for T1/T2 GBC from 2004 to 2014 were identified in the Surveillance, Epidemiology, and End Results database. The effect of lymph node excision (LNE) on survival was assessed using Cox regression and propensity score methods. A total of 2112 patients were identified: 11.4% had T1a, 18.5% T1b, and 70.1% had T2 tumors. Mean follow-up was 31.3 months. In 48.8% of patients, LNE was performed with a mean of 3.6 ± 4.3 nodes retrieved. Cancer-specific 5-year survival for T1 and T2 stages combined was 49.6% (95% confidence interval (CI), 45.9–53.6%) without LNE compared to 56.2% (95% CI, 52.4–60.4%) if LNE was performed (hazard ratio (HR), 0.75; 95%CI, 0.64–0.86, P |
| Databáze: | OpenAIRE |
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