Epidemiological and immunochemical parameters of monoclonal plasma cell dyscrasias of 2121 cases in Algeria

Autor: M. Ghaffor, M. Belhani, Brahim Belaid, Ines Allam, S. Nekkal, M. Saidani, Y. Berkouk, R. Belouni, Lilya Berkani, Reda Djidjik, K. Cherguelaine
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
Immunofixation
medicine.medical_specialty
Adolescent
Myeloma protein
Paraproteinemias
Comorbidity
Monoclonal Gammopathy of Undetermined Significance
Gastroenterology
Immunoglobulin D
General Biochemistry
Genetics and Molecular Biology
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
Humans
Medicine
Sex Distribution
Child
Multiple myeloma
Aged
Retrospective Studies
Aged
80 and over
biology
medicine.diagnostic_test
business.industry
General Medicine
Middle Aged
medicine.disease
Isotype
Immunoglobulin Isotypes
030104 developmental biology
Immunoglobulin M
Algeria
030220 oncology & carcinogenesis
Serum protein electrophoresis
Monoclonal
biology.protein
Female
Immunoglobulin Light Chains
Multiple Myeloma
business
Monoclonal gammopathy of undetermined significance
Paraproteins
Zdroj: Current Research in Translational Medicine. 68:67-70
ISSN: 2452-3186
DOI: 10.1016/j.retram.2019.11.003
Popis: Background Plasma cell dyscrasias (PCD) are a heterogeneous group of diseases characterized by the expansion of monoclonal bone marrow plasma cells that produce a monoclonal immunoglobulin (M-component). Purpose This is a retrospective study that describes the epidemiological, immunochemical features and etiology of monoclonal gammopathies diagnosed between 1998 and 2016 in the Teaching Hospital Beni-Messous of Algiers. Patients and methods 2121 cases of monoclonal gammopathies (MG) were collected during this period. Serum/urine protein electrophoresis, serum/urine immunofixation and serum free light chain measurements were used to demonstrate M protein. Results The middle age of the patients at the time of the diagnosis were 62.96 ± 13.19 years with extremes ranging from 07 to 99 years. The study included 1013 (47, 76 %) men and 1108 (52, 23 %) women with a sex ratio 0,91. Isotypes repartition was: IgG (60.91 %), IgA (17.91 %), light chain (10.46 %), IgM (6.6 %), IgD (1.03 %) and IgE (0.09 %) of cases. The most frequent diagnosis was: Multiple Myeloma (55.20 %), followed by monoclonal gammopathy of undetermined significance (34.13 %). Conclusion In our study, two particularities were noted. There is no male predominance in Algerian PCD patients. Moreover, we observed a higher frequency of light chain multiple myeloma and lower frequency of IgM isotype compared to western studies.
Databáze: OpenAIRE
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