Carcinogenesis‑related changes in iron metabolism in chronic obstructive pulmonary disease subjects with lung cancer
| Autor: | Kamil Brzóska, Jacek Kołakowski, Jacek Grudny, Lucyna Kapka‑Skrzypczak, Paweł Śliwiński, Kazimierz Roszkowski‑Śliż, Barbara Sochanowicz, Marcin Kruszewski, Teresa Bartłomiejczyk, Magdalena Cymerman |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty 03 medical and health sciences 0302 clinical medicine Blood serum Internal medicine medicine Lung cancer Soluble transferrin receptor chemistry.chemical_classification COPD biology business.industry Haptoglobin Articles medicine.disease Blood proteins respiratory tract diseases Ferritin 030104 developmental biology Endocrinology Oncology chemistry Transferrin 030220 oncology & carcinogenesis biology.protein business |
| Zdroj: | Oncology Letters. |
| ISSN: | 1792-1082 1792-1074 |
| DOI: | 10.3892/ol.2018.9459 |
| Popis: | Chronic obstructive pulmonary disease (COPD) is often accompanied by lung cancer. In our previous work, it was observed that matrix metalloproteinase-3 and haptoglobin (HP) polymorphisms were potential markers of enhanced susceptibility to lung cancer development among male COPD subjects. Here, results are reported on blood serum levels of several proteins involved in iron metabolism, inflammation and the oxidative stress response compared between the same groups of subjects. The blood serum levels of tumor necrosis factor α (TNFα), transferrin, hepcidin, ferritin, soluble transferrin receptor and 8-oxo-2′-deoxyguanosine were compared, as well as total iron-binding capacity (TIBC) and ceruloplasmin ferroxidase activity in two groups of subjects: Male COPD patients (54 subjects) and male COPD patients diagnosed with lung cancer (53 subjects). Statistically significant differences were identified between the two groups in transferrin and TNFα levels, as well as in TIBC; all three parameters were lower in the group consisting of COPD patients diagnosed with lung cancer (P |
| Databáze: | OpenAIRE |
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